During our teens and our 20s, our hormonal sex drive is firing on all cylinders.
But as we age, our bodies begin to lessen this drive and this often leads both reduced libido and decreased sexual desire.
For men specifically, this manifests in the form of erectile dysfunction (ED) where it becomes difficult to achieve and/or maintain an erection.
This distressing condition can significantly impact their sexual and emotional health.
Moreso, it might also signal a more serious underlying health issue requiring immediate medical attention (ex. current/future cardiovascular problems).
And while ED medications can increase libido and restore erectile function, they don’t always work and can come with a range of unwanted side effects.
Fortunately, using peptides for ED can be a safer and more effective solution for restoring male sexual health.
In this new article, we’ll talk about how and why peptide therapy will soon become the new breakthrough for treating erectile dysfunction.
What is Peptide Therapy for Erectile Dysfunction?
Erectile dysfunction, defined as the inability of men to achieve or maintain erection during sexual intercourse, can greatly impact a man’s self-confidence and strain their relationships with sexual partners.
It most commonly affects men ages 40-70 and often leads to both reduced libido and diminished sexual performance.
To help improve penile response, some men opt for prescription medications such as Viagra (i.e. the “little blue pill”) and or Cialis.
But as stated in the introduction, therapeutic peptides may be the superior choice.
Peptides are small chains of amino acids stringed together that form protein blocks in the body.
They act as signaling molecules, communicating between tissues to support various bodily functions such as increasing testosterone levels.
There are thousands of peptides are found naturally in younger men, but their production in the body tend to decline with age.
This often leads to several downstream problems, some of which include lowered libido and erectile dysfunction.
In this context, peptide therapy can help boost your body’s natural production of peptides and improve symptoms of ED such as diminished sexual arousal.
And this can often happen within minutes or hours after treatment!
This makes peptide therapy a potent solution for treating erectile dysfunction and thereby improving sexual health.
The Benefits of Peptides for ED and Sexual Health
Certain peptides for men over 50 can help improve erectile dysfunction and sexual health in several ways.
First, peptides may help boost serum testosterone levels by triggering your body to release growth hormone.
This helps increase sex drive and stimulate production of sperm cells.
Second, peptides may stimulate new neural activity to help improve penile function via generating sexual arousal and intense yet long-lasting erections.
The downstream effect is an improvement in your your psychological well-being and cognitive health.
Keep reading and we’ll explore specifically how peptides are able to accomplish these benefits.
The Best Peptide for Erectile Dysfunction Treatment
Let’s dive straight into the best peptide for erectile dysfunction treatment: PT-141.
PT-141 (Bremelanotide)
PT-141, also known as Bremelanotide or Vyleesi, is a powerful peptide that activates internal pathways in the brain involved in normal sexual responses.
This synthetic peptide is created from a naturally occurring hormone called melanocortin that is known to play a key role in sexual arousal.
It’s no wonder many of its users refer to it as “the sex peptide.”
The PT-141 peptide works by binding to melanocortin receptors located in the hypothalamus within the brain.
Once PT-141 binds to these receptors, it sends a cascade of biological signals to other parts of the brain that are involved in sexual arousal.
Consequently, it enhances your sexual performance by generating sexual arousal while allowing for longer-lasting erections.
In fact, many users feel the effects of PT-141 therapy working within minutes to hours of administration.
In a study published in the International Journal of Impotence Research, men who didn’t respond well to Viagra and had low sexual desire were given PT-141.
Doses above 1 mg of bremelanotide significantly improved their erections while also helping address low libido:
“PT-141, a cyclic heptapeptide melanocortin analog, was evaluated following subcutaneous administration to healthy male subjects and to patients with erectile dysfunction (ED) who report an inadequate response to Viagra®.
An inadequate response was defined for this study by patient report indicating that achievement of an erection suitable for vaginal penetration occurred ≤50% of the time while taking 100 mg Viagra®.
Erectile responses were assessed by RigiScan™ in healthy subjects in the absence of visual sexual stimulation (VSS) and in ED patients in the presence of VSS.
Doses ranging from 0.3 to 10 mg were administered to healthy male subjects, resulting in a statistically significant erectile response at doses greater than 1.0 mg.
ED patients were treated with placebo, 4 or 6 mg PT-141 in a crossover design in the presence of VSS.
The erectile response induced by PT-141 was statistically significant at both doses. PT-141 was safe and well tolerated in both studies.
The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.”
Another study in the World Journal of Men’s Health also found that combining sildenafil (Viagra) with 7.5 mg of intranasal bremelanotide resulted in longer-lasting erections compared to using sildenafil alone.
This combination not only improved erection duration but also helped men fix their persistently low sex drive:
“Bremelanotide is a carboxylated metabolite of MT-II, and was formerly known as PT-141.
Bremelanotide is delivered intranasally using a disposable, single-use, metered dose delivery device.
In the phase 1 study, of 32 healthy male subjects, the 10 mg and 20 mg doses of PT-141 resulted in a significantly greater duration of base rigidity ≥80%.
Doses up to 20 mg PT-141 were safely administered to healthy male subjects.
In the phase 2A study, the administration of a 20 mg PT141 dose led to significantly greater duration of base rigidity ≥80% compared to placebo.
Mean duration of base rigidity ≥80% was about 24 minutes at 20 mg dose.
The duration of onset was approximately 30 minutes. Single doses up to 20 mg were safely administrated and well-tolerated in most ED patients.
Another study evaluated the effect of stem cell (SC) administration of PT-141 on healthy subjects and on patients with ED who reported an inadequate response to sildenafil.
The erectile response increased significantly at 4 mg and 6 mg SC doses of PT-141 with VSS.
Single doses up to 10 mg (healthy male subjects) and up to 6 mg (ED patients) of PT-141 were safely administered and well-tolerated.
In an at-home setting, the 342 ED patients who were non-responsive to sildenafil citrate were randomly divided to receive either PT-141 (10 mg) as an intranasally spray or placebo between 2 hours and 45 minutes before sexual activity.
The efficacy of the treatment was assessed using the international index of erectile function (IIEF) score, the mean intercourse satisfaction domain, and number of weekly coitus episodes.
In the bremelanotide group, 51 subjects (34%) reported significantly better results compared to placebo (9%), including ability to attain and maintain an erection sufficient to allow sexual intercourse, and greater intercourse satisfaction.
Reported adverse effects were similar to other studies. A study for co-administration of PT-141 and a PDE5-I was also conducted in 19 men with ED who were responders to sildenafil or vardenafil in order to evaluate an addictive or synergistic effect on erectile response.
The erectile response induced by co-administration of PT-141 (7.5 mg) and sildenafil (25 mg) was significantly greater than the response elicited by administration of sildenafil alone
The combination regimen was safe and well-tolerated and did not result in new adverse events or adverse events that were increased in frequency or severity compared with monotherapy.”
Therefore, if you want to boost your erectile health, improve your libido, and enhance youroverall sexual performance, PT-141 is a powerful solution.
As always, make sure to consult with your doctor for the correct PT-141 dosage before adding it to your daily routine.
Other Peptides for Sexual Health
Apart from PT-141, there are other peptides that can help improve other aspects of your sexual health and wellness.
Melanotan II
Melanotan 2 (MT-2) is a synthetic analog of α-melanocyte-stimulating hormone, which is a naturally occurring peptide hormone in your body.
Melanotan 2 binds to melanocortin receptors such as MC-1R, which stimulates melanin production and results in darkened skin.
More importantly, MT-2 has also been found to help enhance sexual arousal and induce penile erections in men by binding to another melanocortin receptor known as MC-4R.
A study in The Journal of Urology showed men with psychogenic erectile dysfunction successfully had erections upon treatment with MT-2:
“Ten men with erectile dysfunction of no known organic cause were entered in a double-blind, placebo controlled crossover study in which the erectogenic properties of Melanotan-II and a vehicle placebo were compared using real-time RigiScan [double dagger] monitoring.
The presence, duration and rigidity of erections were recorded during a 6-hour period.
In 8 of 10 men treated with Melanotan-II clinically apparent erections developed.
Mean duration of tip rigidity greater than 80% was 38.0 minutes with Melanotan-II and 3.0 with placebo (p = 0.0045).
Transient side effects of nausea, stretching and yawning and decreased appetite were reported more frequently after injections of Melanotan-II than placebo but none required treatment.
Melanotan-II is a potent initiator of erections in men with psychogenic erectile dysfunction and has manageable side effects at a dose of 0.025 mg./kg.”
In another study published in Urology, men with erectile dysfunction who underwent MT-2 treatment demonstrated an increase in sexual desire and penile erection without any sexual stimulation:
“Ten subjects were enrolled in a double-blind, placebo-controlled, crossover study. Melanotan II (0.025 mg/kg) and vehicle were each administered twice by subcutaneous injection; real-time RigiScan monitoring and a visual analog were used to quantify the erections during a 6-hour period.
The level of sexual desire and side effects were recorded with a questionnaire.
As a result, Melanotan II initiated subjectively reported erections in 12 of 19 injections versus only 1 of 21 doses of placebo.
The mean rigidity score of the responders was 6.9 on a scale of 0 to 10.
The mean duration of tip rigidity greater than 80% was 45.3 minutes with Melanotan II versus 1.9 for placebo (P = 0.047).
The level of sexual desire after injection was significantly higher after Melanotan II administration than after placebo.
Nausea and stretching/yawning occurred more frequently with Melanotan II, and 4 of 19 injections were associated with severe nausea.
Hence, the erectogenic properties of Melanotan II are not limited to cases of psychogenic erectile dysfunction; men with a variety of organic risk factors developed penile erections.
The finding of increased sexual desire warrants further investigation of centrally acting agents on disorders of sexual desire.”
Kisspeptin
Kisspeptin is a peptide produced by the hypothalamus in the brain.
It plays an important role in human reproduction, aldosterone secretion (which regulates water and salt balance), tumor suppression, and kidney function.
The Kisspeptin peptide works by binding to the G-protein-coupled receptor (GPCR).
This in turn stimulates the release of gonadotropin-releasing hormone (GnRH), leading to the secretion of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and other sexual steroids.
These secreted hormones/steroids act on the gonads to stimulate the production of reproductive cells such as egg cells and sperm cells.
Therefore, by affecting the circulating levels of the hormones LH and FSH, kisspeptin increases your testosterone levels.
And this in turn improves your overall sexual desire and erectile function.
In one from The Journal of Clinical Endocrinology & Metabolism involving male volunteers, an intravenous (IV) infusion of kisspeptin significantly increased blood levels of LH, FSH, and testosterone concentrations compared with a placebo (saline) infusion:
“This was a double-blind, placebo-controlled, crossover study. This was a hospital-based study.
Male volunteers were recruited.
Each volunteer received a 90-min iv infusion of kisspeptin-54 (4 pmol/kg·min) and a control infusion of saline (0.9%) in random order.
Plasma LH, FSH, and testosterone concentrations were measured.
Kisspeptin-54 infusion significantly increased plasma LH, FSH, and testosterone concentrations compared with saline infusion (mean 90-min LH: kisspeptin, 10.8 ± 1.5 vs. saline, 4.2 ± 0.5 U/liter, P < 0.001; mean 90-min FSH: kisspeptin, 3.9 ± 0.7 vs. saline, 3.2 ± 0.6 U/liter, P < 0.001; mean 180-min testosterone: kisspeptin, 24.9 ± 1.7 vs. saline, 21.7 ± 2.2 nmol/liter, P < 0.001).
The plasma half-life of kisspeptin-54 was calculated to be 27.6 ± 1.1 min.
The mean metabolic clearance rate was 3.2 ± 0.2 ml/kg·min, and the volume of distribution was 128.9 ± 12.5 ml/kg.
Therefore, elevation of plasma concentrations of kisspeptin in human males significantly increases circulating LH, FSH, and testosterone levels.
Kisspeptin infusion provides a novel mechanism for hypothalamic-pituitary-gonadal axis manipulation in disorders of the reproductive system.”
Another study in Clinical Endocrinology showed how kisspeptin-10 administration increased LH pulse frequency and LH secretion, which increased blood levels of testosterone in men with type 2 diabetes and mild biochemical hypogonadism:
“Five hypotestosteronaemic men with T2DM (age 33·6 ± 3 years, BMI 40·6 ± 6·3, total testosterone 8·5 ± 1·0 nmol/l, LH 4·7 ± 0·7 IU/l, HbA1c 7·4±2%, duration of diabetes <5 years) and seven age-matched healthy men.
For experiment 1, mean LH increased in response to intravenous administration of kisspeptin-10 (0·3 mcg/kg bolus) both in healthy men (5·5 ± 0·8 to 13·9 ± 1·7 IU/l P < 0·001) and in men with T2DM (4·7 ± 0·7 to 10·7 ± 1·2 IU/l P = 0·02) with comparable ΔLH (P = 0·18).
While for experiment 2, baseline 10-min serum sampling for LH and hourly testosterone measurements were performed in four T2DM men over 12 h.
An intravenous infusion of kisspeptin-10 (4 mcg/kg/h) was administered for 11 h, 5 days later.
There were increases in LH (3·9 ± 0·1 IU/l to 20·7 ± 1·1 IU/l P = 0·03) and testosterone (8·5 ± 1·0 to 11·4 ± 0·9 nmol/l, P = 0·002).
LH pulse frequency increased from 0·6 ± 0·1 to 0·9 ± 0 pulses/h (P = 0·05) and pulsatile component of LH secretion from 32·1 ± 8·0 IU/l to 140·2 ± 23·0 IU/l (P = 0·007).
This just shows that Kisspeptin-10 administration increased LH pulse frequency and LH secretion in hypotestosteronaemic men with T2DM in this proof-of-concept study, with associated increases in serum testosterone.
These data suggest a potential novel therapeutic role for kisspeptin agonists in enhancing endogenous testosterone secretion in men with T2DM and central hypogonadism.”
GHRPs (Growth Hormone-Releasing Peptides)
Growth hormone-releasing peptides (GHRPs) are a class of synthetic peptides designed to stimulate the release of growth hormone (GH) from the pituitary gland.
They work by mimicking the effects of ghrelin, a hormone naturally produced in the stomach that promotes hunger and stimulates GH release.
Once a GHRP binds to the ghrelin receptors in the pituitary gland, growth hormone is released and this positively affects a wide range of bodily functions.
Growth hormone-releasing peptides such as select heptapeptides (GHRP-1) and hexapeptides (GHRP-2, GHRP-6, hexarelin) have been shown to be effective releasers of GH in animals and humans.
While their primary function is to stimulate the release of growth hormone, they have also been shown to positively impact male reproductive sexual health.
They directly and indirectly do this by:
- Improving gonad response to hormones
- Possibly influencing sperm production
- Regulating erectile function
Therefore, an increase in GH may enhance one’s sexual health.
In fact, a study in the Journal of the Endocrine Society proves how sexual dysfunction is strongly correlated with growth hormone deficiency:
“83 Adult Growth Hormone Deficiency (AGHD) patients (31 women, 52 men, mean age 56.3 ± 14.7 years) were enrolled according to stringent criteria.
Patients were divided into two groups: Group 1 (n = 32)
are patients already on long-term r-hGH therapy while Group 2 (n = 51) are untreated patients.
Main outcome measures are Serum hormones, QoL Satisfaction in Hypopituitarism (QLS-H) and QoL Assessment of GHD in Adults (QoL-AGHDA) questionnaires for QoL, Index for Erectile Function-15 (IIEF-15) in men, and Female Sexual Function Index (FSFI) in women for SD.
Results show that the overall prevalence of Sexual Dysfunction (SD) was 71.2% (60% men, 89% women).
All Index for IIEF-15 scores were lower (P = 0.001) and erectile dysfunction was more prevalent in Group 2 (75%) than Group 1 (35%).
IGF-1 was correlated to scores of all IIEF-15 domains, particularly with that of erectile function (EF) (R2=0.123, P = 0.019).
EF domain score correlated with QLS-H (P < 0.005) and QoL-AGHDA (P = 0.001).
Despite the high prevalence of female SD also in untreated AGHD women, FSFI scores did not correlate with IGF-1 levels and QoL scores.
Overall, this study shows that Sexual Dysfunction is highly prevalent in AGHD patients, especially in those untreated.”
Similarly, a study in the European Journal of Pharmacology showed that EP 80661 and other hexarelin peptide analogs induced penile erection in male rats:
“The effect of GAB-d-Trp(2-Me)-d-Trp(2-Me)-LysNH2 (EP 80661), GAB-d-Trp(2-Me)-d-Trp(2-Me)-d-Trp(2-Me)-LysNH2 (EP 60761), GAB-d-Trp(2-Me)-LysNH2 (EP 91071) and GAB-d-Trp(2-Me)-d-βNal-Phe-LysNH2 (EP 50885), four hexarelin peptide analogues that induce penile erection when injected into the paraventricular nucleus of the hypothalamus of male rats, on the concentration of NO2− and NO3− in the paraventricular dialysate was studied in male rats.
EP peptides (1 μg) induced penile erection and increased the concentration of NO2− and NO3− in the paraventricular dialysate.
In contrast, hexarelin (1 μg) was ineffective on either penile erection or paraventricular NO2− and NO3−.
EP peptide-induced penile erection was prevented by the nitric oxide synthase inhibitor NG-nitro-l-arginine methylester given into the paraventricular nucleus (20 μg), which also reduced the concomitant increase of NO2− and NO3− concentration in the paraventricular dialysate.
In contrast, the oxytocin receptor antagonist [d(CH2)5Tyr(Me)2-Orn8]vasotocin (1 μg) given into the paraventricular nucleus, was ineffective on penile erection and on the NO2− and NO3− increase induced by EP peptides, despite its ability to prevent the sexual response induced by the above peptides when given into the lateral ventricles.
The present results show that EP peptides induce penile erection by activating nitric oxide synthase in the paraventricular nucleus of the hypothalamus, possibly in the cell bodies of oxytocinergic neurons that control penile erection.”
Potential Side Effects and Considerations
Peptide therapy is a promising option for erectile dysfunction and sexual health, but it may also come with side effects.
Below is a list of potential side effects you may experience, whether as a first-time user or a peptide veteran:
- Nausea
- Headache
- Vomiting
- Flushing
- Feeling hot
- Agitation
- Facial flushing
- Fatigue
- Increased moles and freckles
- Loss of appetite
- Spontaneous erections
- Diarrhea
- Excessive sweating
- Blurred vision
- Darkening of skin or gums (people with darker skin color are at higher risk)
- Joint stiffness
To avoid unwanted side effects, it’s crucial to consult with your doctor about the proper dosage for each peptide to avoid misuse via overdosing.
Other Treatment Options for ED
In addition to peptide therapy, various other treatment options are available to enhance sexual well-being.
These options can address erectile dysfunction, boost sexual performance, increase arousal, and support stronger yet long-lasting erections.
Some of these optoins include:
- Shockwave therapy devices such as The Phoenix
- Testosterone replacement therapy (TRT)
- Other non-pharmaceutical methods to restore sexual health
Among these choices, peptide therapy stands out as one of the safest and most effective alternatives.
Since peptides are naturally occurring in the body, peptide therapy is generally well tolerated by most patients.
However, it is perfectly fine to combine peptides with the other modalities mentioned above to get the most bang for your buck!
Key Takeaways and Where to Find PT-141 for Peptide Therapy
If you’re someone who suffers from erectile dysfunction and you want to boost your sexual health once again, consider peptide therapy!
It’s been proven safe and effective at increasing your sexual desire and enhancing penile response so you can feel confident about yourself and enjoy satisfying intimate moments once again.
Make sure to buy your peptides only from reputable sources like Limitless Biotech to guarantee their quality, safety, and effectiveness.
They have the best formulations of experimental compounds available, and no other vendor comes close to offering them at ultra-high levels of purity for reasonable prices.
Use code JAY15 to get 15% off your order of NON-VIP peptides like Kisspeptin and 5% off VIP peptides like PT-141
But even if you aren’t ready to jump on the peptides bandwagon just yet…
Make sure you read the Top 10 Mistakes People Make When Starting Therapeutic Peptides FREE PDF before you place a single order!
Seriously, this short e-book will save you a lot of wasted money and poorly spent time (not to mention preventing you from potential self-inflicted missteps).
And the emails I’ll send you after downloading the book contain EXCLUSIVE 20% OFF discount codes code for all my amazing courses on using therapeutic peptides, such as:
Peptides Demystified (THE #1 course for newbies when learning to use peptides)
The Modern Woman’s Peptide Course (A course made by women for women on using therapeutic peptides)
The Ultimate GLP-1 Video Masterclass (Learn how to use GLP-1 peptides to live leaner, longer & stronger)
Raise Your Vibration To Optimize Your Love Creation!
PS — Are you looking to biohack your best life through the smart use of therapeutic peptides and other Golden Age agents?
Join me and hundreds of other male and female biohackers in The Fully Optimized Health Private Membership Group to learn how you can use peptides to optimize your health as you age.
See you on the other side!
