- Jay's Protocol
Jay Campbell's Mitochondria Protocol
More energy. Sharper output. Compounds that target the root of how your body produces and sustains power.
Goal: Mitochondrial Optimization & Metabolic Performance
- Protocol Overview
This isn’t about surface-level energy support.
It’s what serious men use when they want to go after mitochondrial function directly — increasing biogenesis, improving metabolic efficiency, clearing dysfunctional cells, and keeping the energy systems that drive everything else running at full capacity.
Compounds
5
Protocol Duration
8–12 weeks
Administration
Mixed
Best For
Men 35–65, intermediate to advanced
This protocol is for you if:
- You've optimized the basics and want to go deeper into cellular energy production
- Your energy output has stalled despite good training, sleep, and nutrition
- You want compounds that work at the mitochondrial level — not stimulants that mask the problem
- You're focused on long-term metabolic health and performance, not a quick fix
This protocol is NOT for you if:
-
You're brand new to peptides — start with the
Reconstitution Course first - You haven't had recent bloodwork done
- You're not currently strength training consistently
The Compounds
ShredMAX
What It Does: ShredMAX contains SLU-PP-332, a research-grade ERR receptor agonist that activates all three estrogen-related receptor subtypes — ERRα, ERRβ, and ERRγ — directly driving mitochondrial biogenesis, fat oxidation, and improved exercise capacity.
Protocol Details:
Dose
1 cap AM + PM
Timing
AM and PM
Frequency
Daily
Duration
Ongoing use
Administration
Capsule
Source
Jay’s Note: SLU-PP-332 is one of the most direct mitochondrial biogenesis compounds I’ve run. ShredMAX keeps your cellular energy engine turning over while the rest of this stack builds the infrastructure around it.
BioAmpMAX
What It Does: A six-compound oral stack built around ATX-304 (OS-01) and 5-Amino-1MQ, with Myo-Inositol, D-Chiro-Inositol, Chromium Picolinate, and NAC added to support glucose control, insulin sensitivity, and mitochondrial energy metabolism from multiple angles simultaneously.
Protocol Details:
Dose
Beginner: 1 cap AM / Intermediate: 1–2 caps AM & PM / Advanced: 3 caps AM & PM
Timing
AM or PM
Frequency
Daily
Duration
8–12 weeks on, equal time off
Administration
Capsule
Source
Jay’s Note: BioAmpMAX is the oral foundation of this protocol. Start at 1 cap in the AM and assess your response before moving to twice-daily dosing.
MOTS-C
What It Does: A mitochondria-derived peptide that activates AMPK signaling and directly improves mitochondrial biogenesis and metabolic flexibility. MOTS-C is one of the few compounds that signals from the mitochondria itself — it’s not mimicking that process, it IS that process.
Protocol Details:
Dose
1 mg
Timing
AM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: MOTS-C is unlike anything else in this stack — it originates from within the mitochondria. The research on AMPK activation and metabolic regulation here is some of the most compelling I’ve seen. Run it fasted in the AM.
5-Amino-1MQ
What It Does: A small molecule NNMT inhibitor that raises intracellular NAD+ levels by blocking the enzyme responsible for depleting them. Higher NAD+ means more fuel for mitochondrial function, better fat oxidation, and improved metabolic rate — without the delivery limitations of oral NAD+ supplementation.
Protocol Details:
Dose
1 mg (10 units on 1ml insulin syringe)
Timing
AM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: 5-Amino-1MQ works by stopping NAD+ from being consumed at the source. That’s a completely different mechanism from just taking NAD+ directly — and it’s more targeted because of it.
Metabolic Blend (NAD+ / MOTS-C / 5-Amino-1MQ)
What It Does: A pre-compounded injectable blend combining NAD+ (100 mg), MOTS-C (10 mg), and 5-Amino-1MQ (10 mg) in a single vial. For those who want the full mitochondrial triad in one injection rather than running each compound separately.
Protocol Details:
Dose
500 mcg / 1 mg (10 units on 1ml insulin syringe)
Timing
AM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: If you want to simplify the injectable side of this protocol down to one shot, the Metabolic Blend is the cleanest way to do it. Everything you need from the mitochondrial triad, one injection, one draw.
How to Run This Protocol
01
Before You Start:
- Get bloodwork done. You need a baseline before you add anything to your system.
- Without it, you're guessing — and guessing is how people miss what's working and ignore what isn't.
02
Running the Stack:
- Follow each compound's individual cycle timing exactly as written.
- Don't compress the off-weeks and don't extend the on-weeks because you're feeling good.
- The cycle structure isn't arbitrary — it's how you maintain receptor sensitivity and keep the compounds working the way they're supposed to.
03
What to Track:
- Run follow-up bloodwork at the six-week mark and again at protocol completion.
- Track your numbers alongside how you actually feel — energy, sleep quality, recovery between sessions, and body composition changes.
04
Common Mistakes:
- Starting without a baseline. If you don't know where you started, you can't know what moved.
- Abandoning the protocol too early. Most of these compounds need four to six weeks before you feel the full effect.
- Skipping the off-weeks. The off-weeks are part of the protocol.
Frequently Asked Questions
Can I run this protocol while on TRT?
Yes — TRT is a strong foundation to build this protocol on top of.
Testosterone itself plays a role in mitochondrial function, and keeping your T optimized means the metabolic compounds in this stack have less interference to overcome.
Run your TRT protocol as normal and add these compounds on top
Get bloodwork at the six-week mark to confirm your key metabolic markers are trending in the right direction.
Can I run the Metabolic Blend AND the standalone MOTS-C and 5-Amino-1MQ injections together?
No — pick one approach.
Either run MOTS-C and 5-Amino-1MQ as separate injections, or use the Metabolic Blend.
Running both simultaneously means you’re doubling the dose of each compound without a clinical reason to do so.
Keep it clean.
Do I need to cycle off?
Yes.
Follow the individual cycle guidelines for each compound.
MOTS-C, 5-Amino-1MQ, and the Metabolic Blend all run 8 weeks on, 8 weeks off.
BioAmpMAX runs 8–12 weeks on, equal time off.
ShredMAX can be used on an ongoing basis, but monitor your response.
Your body needs the off-periods to consolidate adaptation and maintain sensitivity.
What if I'm a peptide beginner?
If you haven’t reconstituted or injected peptides before, start with the Reconstitution Course. It covers everything you need to do this safely.
Come back to this stack once you’ve run a simpler protocol first.
Get Fully Optimized with Jay
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