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Ipamorelin: A Peptide for Women’s Hormonal Imbalance?

ipamorelin for women

Did you know nearly half of American women between the ages of 30-60 unknowingly experience symptoms of hormonal imbalance

Hormonal imbalances can occur when there’s over- or underproduction of a particular hormone, thereby leading to negative health outcomes (fatigue, reduced sex drive, difficulty losing weight, etc.).

These imbalances can be caused by various factors – both internal and external – and it takes only a slight imbalance for some of the unwanted outcomes described above to appear.

So naturally, restoring a woman’s hormones to optimal levels will help her:

  • Feel rejuvenated
  • Be more confident
  • Look better than ever
  • Restore libido
  • Finally start losing weight again

But in situations where healthy lifestyle habits are helpful but not enough, a therapeutic peptide like Ipamorelin can help women achieve optimal hormonal health.

In this article, we’ll explore the potential health benefits of Ipamorelin and dive deeper into which hormones are targeted.

What is Ipamorelin?

ipamorelin for women

Ipamorelin, a growth hormone-releasing peptide (GHRP), stimulates the pituitary gland to release human growth hormone (hGH) and increase levels of insulin-like growth factor 1 (IGF-1) in the body.

But this fast-acting pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), with a biological half-life of about 2 hours after administration, can do a lot more.

Ipamorelin also suppresses the release of somatostatin, a hormone that works to inhibit the release of growth hormone.

Furthermore, Ipamorelin has been shown in studies to not interfere with the body’s follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, or thyrotropin-releasing hormone (TSH) levels.

It also doesn’t negatively affect cortisol or ACTH levels, even during GHRH stimulation.

Should Women Use Ipamorelin?

Ipamorelin isn’t just for athletes or bodybuilders who want to get shredded or build muscle.

Since it increases both HGH and IGF-1 levels, the peptide also offers a wide range of benefits for women such as elevated energy levels, deeper sleep, and improved heart health.

Ipamorelin can also reduce fat storage while promoting lean muscle mass, giving women a more aesthetic physique (assuming they’re already living an insulin-controlled lifestyle)

Can Peptide Therapy Help with Hormonal Balance?

ipamorelin for women

Peptides for women’s health play a crucial role in regulating hormone production and function in the body, which itself affects everything from metabolism to mood. 

To be more exact, peptides can help manage conditions specific to women like menopause, thyroid disorders, and adrenal fatigue.

All of these can cause (or are caused by) hormonal imbalances, leading to issues like weight gain, fatigue, mood swings, and decreased libido. 

Fortunately, peptide therapy can support the health of hormone-producing organs such as the pituitary gland, thyroid, and adrenal glands to ensure a woman’s hormonal health is fully optimized at all times.

And Ipamorelin can definitely be a part of said therapy.

For instance, its anti-inflammatory properties lead to an improvement in insulin sensitivity, which helps regulate blood sugar levels and prevent metabolic disorders.

Plus, it might even be useful in the context of menopause relief

But we’ll explore exactly how Ipamorelin is useful for female hormone optimization in the next section.

Benefits of Ipamorelin for Women

ipamorelin for women

Thinking of using Ipamorelin? Below are some of the top benefits of Ipamorelin for women’s health.

Hormonal Balance and Regulation

Ipamorelin can help restore hormonal balance in women via regulating fertility, menstrual cycles, and menopausal symptoms.

For example, women struggling with infertility who were treated with growth hormone peptides like Ipamorelin saw an increase in uterine size, leading to improved pregnancy rates:

“Treatment with growth hormone-releasing factor (GRF) has been reported to improve the ovarian response to gonadotrophins in women who respond poorly to ovarian stimulation during in-vitro fertilization (IVF). 

The efficacy and tolerability of GRF were studied in a randomized, double-blind, placebo-controlled trial involving 196 patients. 

Following down-regulation with a gonadotrophin-releasing hormone agonist (GnRHa), patients were randomized to receive GRF (500 microg twice daily; n = 96) or placebo (n = 100) in addition to follicle stimulating hormone (FSH); treatment was continued until human chorionic gonadotrophin was given, or for a maximum of 14 days. 

GRF had no significant effect on the mean number of follicles with a diameter of >/=16 mm (GRF: 3.26 +/- 2.29; placebo: 3.27 +/- 2.30; P = 0.95), the number of FSH ampoules required to achieve ovarian stimulation (GRF: 55.2 +/- 16. 4; placebo: 54.9 +/- 17.2; P = 0.50), or on secondary measures of ovarian response and treatment outcome. 

There were, however, significant increases in circulating growth hormone (GH) and insulin-like growth factor (IGF)-1 concentrations. 

GRF was well tolerated. It is concluded that, despite producing significant increases in GH and IGF-1, concomitant treatment with GRF does not improve the ovarian response to FSH in poorly responsive women undergoing IVF.”

Body Composition

If you want to lose body fat while building lean muscle mass, Ipamorelin is one of the best peptide choices you can make for total body recomposition. 

It can also help improve your muscle strength, even if you’re over the age of 50!

This has been shown in a study in the International Journal of Endocrinology where 50 to 70-year-old test subjects experienced significant improvements after 6 months of growth hormone therapy: 

“Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.). 

Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy. Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group). 

Subjects of both groups were not different at baseline. 

After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group. 

Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men. 

This finding must be considered and tested in frail older populations, whose physical incapacity is primarily caused by proximal muscle weakness.”

Whether you’re a man or woman, young or old, Ipamorelin is one of the most effective peptides for weight loss and muscle strength.

Anti-Aging

Ipamorelin is renowned for its natural anti-aging abilities, not just hormonally but also aesthetically.

One of the ways it can help you achieve a more youthful appearance is by increasing collagen production and improving cell repair.

It can also address sagging skin, wrinkles, age spots, and dull skin… helping you maintain a more youthful and vibrant look.

In a study published in Acta Endocrinologica, rats treated with growth hormone peptides like Ipamorelin showed an increase in collagen content and mechanical skin strength after 90 days of consecutive use:

“The influence of biosynthetic human growth hormone on biomechanical properties (strain at maximum load, maximum load, relative failure energy, maximum stiffness) and collagen content of intact rat skin was measured after injection of biosynthetic human growth hormone for 90 days at doses of 0.16, 1.10 and 8.33 mg.kg-1.day-1. 

The mechanical test showed that strain at maximum load, maximum load, and relative failure energy increased with increasing doses of biosynthetic hGH. In the group receiving 8.33 mg.kg-1.day-1, skin collagen content per surface area and skin collagen concentration in percent of dry weight was increased, whereas the fat concentration in percent of dry weight was decreased. 

Also when correcting the mechanical data for cross-sectional area, a positive correlation between dose and relative failure energy was found. 

When dividing the mechanical data by collagen content per surface area of the skin, the maximum stress and relative failure energy reached the highest value at a dose of 1.10 mg.kg-1.day-1. 

The study shows that biosynthetic hGH can induce an increase in collagen content and mechanical strength of intact rat skin which is dependent on the dose of biosynthetic hGH, and that the increase in mechanical strength cannot be explained only by an increased collagen content.”

Therefore, if you’re looking to erase any signs of aging that are showing in your face and other parts of your body, Ipamorelin is a great anti-aging peptide you can rely on.

Bone and Joint Health

Another major yet underappreciated health benefit of Ipamorelin is its ability to support bone health and prevent various bone disorders. 

In a study published in the Journal of Endocrinology, adult female rats given Ipamorelin for 12 weeks had increased bone mineral content without any side effects or toxicities:

“Thirteen-week-old female Sprague-Dawley rats were given IPA (0.5 mg/kg per day; n=7), GHRP-6 (0.5 mg/kg per day; n=8), GH (3.5 mg/kg per day; n=7), or vehicle administered continuously s.c. via osmotic minipumps for 12 weeks. 

The animals were followed in vivo by dual X-ray absorptiometry (DXA) measurements every 4th week. 

After the animals were killed, femurs were analysed in vitro by mid-diaphyseal peripheral quantitative computed tomography (pQCT) scans. 

After this, excised femurs and vertebrae L6 were analysed by the use of Archimedes’ principle and by determinations of ash weights. 

All treatments increased body weight and total tibial and vertebral BMC measured by DXA in vivo compared with vehicle-treated controls. 

However, total BMC corrected for the increase in body weight (total BMC:body weight ratio) was unaffected. 

Tibial area bone mineral density (BMD, BMC/area) was increased, but total and vertebral area BMDs were unchanged. 

The pQCT measurements in vitro revealed that the increase in the cortical BMC was due to an increased cross-sectional bone area, whereas the cortical volumetric BMD was unchanged. 

Femur and vertebra L6 volumes were increased but no effect was seen on the volumetric BMDs as measured by Archimedes’ principle. 

Ash weight was increased by all treatments, but the mineral concentration was unchanged. We conclude that treatment of adult female rats with the GHSs Ipamorelin and GHRP-6 increases BMC as measured by DXA in vivo. 

The results of in vitro measurements using pQCT and Archimedes’ principle, in addition to ash weight determinations, show that the increases in cortical and total BMC were due to an increased growth of the bones with increased bone dimensions, whereas the volumetric BMD was unchanged.”

Ipamorelin can also be used as a peptide for injury recovery because it helps repair damaged tissue caused by physical trauma

This happens via boosting collagen synthesis and providing structural/biochemical support in the cells surrounding the injured area:

“Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. 

However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. 

Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. 

Furthermore, genome-wide association studies have linked components of the (TGFβ) superfamily to susceptibility to osteoarthritis. 

This review focuses on recent discoveries from genetic studies in the mouse regarding the regulation of TGFβ signaling in developing growth plate and articular cartilage, as well as the different modes of crosstalk between canonical and noncanonical TGFβ signaling. 

These new insights into TGFβ signaling in cartilage may open new prospects for therapies that maintain healthy articular cartilage.”

Improved Sleep Quality, Energy Levels, and Mood

Last but not least, Ipamorelin can promote restful sleep by improving both sleep quality and quantity, making it a great peptide for better energy levels.

Patients with growth hormone deficiency who have trouble getting a good night’s sleep were able to sleep faster after four months of Ipamorelin administration, as evidenced by a study published in the European Journal of Endocrinology:

“Fourteen patients with untreated GHD of confirmed or likely pituitary origin, aged 22–74 years, participated in the study. 

Patients with associated hormonal deficiencies were on appropriate replacement therapy. 

Polygraphic sleep recordings, with bedtimes individually tailored to habitual sleep times, were performed after 4 months on rhGH or placebo.

Valid data were obtained in 13 patients. At the end of the rhGH treatment period, patients had a shorter sleep period time than at the end of the placebo period (479±11 vs 431±19 min respectively; P=0.005), primarily due to an earlier wake-up time, and a decrease in the intensity of SWS (delta activity) (559±125 vs 794±219 μV2 respectively; P=0.048).

Four months of rhGH replacement therapy partly reversed sleep disturbances previously observed in untreated patients. 

The decrease in delta activity associated with rhGH treatment adds further evidence to the hypothesis that the excess of high-intensity SWS observed in untreated pituitary GHD patients is likely to result from overactivity of the hypothalamic GHRH system due to the lack of negative feedback inhibition by GH.”

Similarly, rats given the growth hormone-releasing peptide had activated sleep regulatory neurons in the brain, resulting in better sleep:

“Intracerebroventricular administration of GHRH significantly increased (P < 0.001) the amount of NREM sleep compared with the control group of rats at the beginning of the active/dark period. 

A significant increase (P < 0.001) in the EEG SWA was also observed in the GHRH intracerebroventricularly injected rats compared with the control group. 

However, REM sleep amount did not change significantly (P = 0.311) following intracerebroventricular injection of GHRH. 

The latency of NREM sleep onset decreased significantly (P < 0.05) after GHRH treatment (22.50 ± 2.68 min) compared with control saline (34.17 ± 4.57 min) treatment group during the dark period.”

Safety and Side Effects of Ipamorelin for Women

ipamorelin for women

While Ipamorelin is generally considered safe, it has yet to receive approval from the FDA or international regulatory bodies for human use

Therefore, it’s important to be aware of the potential side effects that you may experience from taking Ipamorelin for the first time.

Common outcomes in women include:

  • Headache
  • Nausea
  • Flushing
  • Increased appetite
  • Dizziness
  • Fatigue
  • Hot flashes
  • Chills
  • Anxiety
  • Nervousness
  • Sleep disturbances
  • Joint pain
  • Stiffness
  • Numbness or tingling in the extremities

More serious side effects can include heart palpitations and hypoglycemia, leading to lightheadedness and hunger.

You may also experience increased hunger as Ipamorelin mimics the function of ghrelin, the “hunger hormone.

It’s best to monitor your mood and health closely, as this can help alleviate any side effects and allow you to adjust dosages as needed.

Ipamorelin vs Other Hormone Therapies

ipamorelin for women

While Ipamorelin and other hormone therapies might seem similar in that they both stimulate growth hormone production, they achieve this goal quite differently.

As stated before, Ipamorelin is unique with respect to its reduction of somatostatin and non-interference with cortisol production (which can lead to unwanted side effects such as elevated appetite).

For those two reasons alone, Ipamorelin is considered to be safer and more effective than other hormone therapies for women looking to increase their growth hormone production.

Can Women Take Ipamorelin and CJC-1295?

ipamorelin for women

When it comes to peptides, Ipamorelin and CJC-1295 are THE synergistic “growth hormone” combination. 

Used together, they offer a range of benefits that can keep any woman’s body healthy and performing at its peak.

As already discussed, Ipamorelin boosts growth hormone production in the pituitary gland.

On the other hand, CJC-1295 is a modified form of GHRH (growth hormone-releasing hormone), which on its own enhances growth hormone release.

When these two peptides are combined, they work in harmony and enhance each other’s effects through an increase in growth hormone production not possible with either peptide in isolation. 

Jay’s Closing Thoughts

Years ago, I made a video writing about why Ipamorelin is arguably the best anti-aging peptide for women desiring fat loss, deeper sleep and hormonal optimization:

That opinion has remained entirely unchanged.

Even in The TOT Bible, I said the following:

“A [subcutaneous] injection of 200-300 mcg immediately before bed [for women] can produce dramatic fat loss and improved body composition in less than 3 months (when combined with resistance training, cardiovascular training and insulin-controlled living).”

HOWEVER, I AM of the conviction that pharma-grade human growth hormone is the superior choice if you can get your hands on it.

The next best thing would be the use of Ipamorelin and Tesamorelin together, followed by Ipamorelin and CJC-1295.

Key Takeaways of Ipamorelin for Women

ipamorelin for women

Ipamorelin stands out as a safe and effective peptide for women looking to optimize their hormone levels.

If you’re a woman who is dealing with hormonal imbalances that are affecting your menstrual cycle, fertility, weight, or overall health… definitely consider this peptide as a potentially viable solution.

If you’re curious to learn more about Ipamorelin and how it compares to other peptides, be sure to check out the articles listed below:

Finally, make sure to only use Ipamorelin from a trusted source. 

We highly recommend Limitless Life Nootropics because they are the biohacking industry’s only reliable source for 3rd-party tested research products.

They have the best research formulation of Ipamorelin available and no other vendor in existence is a close second.

(Use code JAY15 to get 15% off your order)

But before you start injecting these peptides into your body recklessly, make sure you first read the Top 10 Mistakes People Make When Starting Therapeutic Peptides FREE PDF!

Seriously, this short e-book will save you a lot of wasted money and poorly spent time (not to mention preventing you from potential self-inflicted missteps).

And the emails I’ll send you after downloading the book contain an EXCLUSIVE 33% OFF code for my Peptides Demystified Course, so don’t miss out!

Raise Your Vibration To Optimize Your Love Creation!

 

PS — Are you looking to maintain optimal hormonal balance through the smart use of therapeutic peptides and other Golden Age agents?

Join me and hundreds of other male and female biohackers in The Fully Optimized Health Private Membership Group to learn how you can use peptides to maintain hormone balance and optimize your health in your 30s and beyond

We’re excited to discuss biohacking, health, and life optimization through peptide therapy with you.

See you on the other side!

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