Every human being on planet Earth, to one degree or another, seeks out the “Fountain of Youth”.
The magic elixir that helps you live as long as possible while looking and feeling as young as possible at the same time.
Whether it’s maintaining the physical performance of an elite athlete, having the cognitive performance of a sharp 20-something in finance, or being able to prevent all lifestyle illnesses from happening, human perfection is what we seek.
We’re not quite there yet, but the best injectable peptides for anti-aging are the closest thing we have to a “Fountain Of Youth” in the Golden Age.
Peptide injection therapy can be defined as the injection of therapeutic peptides into your body subcutaneously (through your fat tissue), intramuscularly (through your muscle tissue), or intravenously (through your veins) for medical and/or aesthetic purposes.
These purposes include healing an injury/illness, improving your appearance, enhancing physical or mental performance, fully optimizing long-term health, and much more.
In 99% of cases, injections tend to be the best way to administer peptides due to their fickle metabolic nature:
“But almost none of these drug-peptides can be taken orally. Since peptides are an important part of food, the stomach and intestines harbor countless enzymes that can degrade them, meaning that most peptide-based medication do not survive the passage through the gastrointestinal tract.”
This effectively means that creams, nasal sprays, and oral formulations are not as useful with respect to their limited absorption and effectiveness in the body.
“Anti-aging treatments are specifically designed to reduce the appearance of wrinkles, fine lines, and sagging skin. These treatments are commonly performed on parts of the body that are most susceptible to the earliest signs of aging, such as the face, neck, and hands”
And this is where the confusion lies: Are we focused on the APPEARANCE of aging, the literal reversal of aging itself so we live longer, or the lifestyle diseases associated with older age?
We have the data to prove their worth, so now it’s just a matter of getting them into mainstream awareness.
The copper peptide GHK-Cu has a long history since its discovery in human blood in the early 1970s by the scientist Loren Pickart, who is responsible for the majority of published studies studying this molecule.
It is a complex formed by the tripeptide “GHK” and copper, an essential mineral for human health and the development of connective tissue.
And as a naturally-occurring peptide, its production in the human body fades with time.
Not only is it a powerful antioxidant with anti-inflammatory properties, but it also repairs damaged DNA and shows some level of immunity protection against bacteria and viruses.
One of GHK-Cu’s primary features is the acceleration of wound healing, primarily via the production of the protein collagen and the stimulation of new blood vessel growth.
“Clinical studies have shown that low-dose growth hormone (GH) treatment for adults with GH deficiency changes the body composition by increasing muscle mass, decreasing fat mass, and increasing bone density and muscle strength.
It also improves cardiovascular parameters (i.e. decrease of LDL cholesterol) and affects the quality of life without significant side effects”
Scientists figured out eons ago that the brain-dead solution of simply injecting HGH is medically unviable for several reasons:
Shut down of the body’s natural production of HGH
Negatively affects your pituitary gland
Higher risk of insulin resistance
Only available as a controlled substance and prescribed for VERY specific medical conditions, especially those focused around lack of normal HGH production at very young ages
This leads us to the two types of anti-aging peptides that can help us stimulate the pathways leading to HGH production WITHOUT affecting our body’s natural means of producing and distributing HGH.
Growth hormone releasing hormone (GHRH): Responsible for the frequency and timing of the body’s “pulses” that secret HGH through increasing production of HGH-releasing cells (somatotropes) and the amount of HGH released by the cells.
Growth hormone releasing peptide (GHRP): Increases the size of the pulses by inhibiting somatostatin production to prevent inhibition of HGH release, and promotes the release of more GHRH.
Smart experiential-based doctors know that combining both a GHRP and a GHRH is the best way to maximize natural HGH production at all times.
Which brings us back to CJC-1295, a small fragment of naturally-occurring GHRH responsible for increasing HGH production.
You’ll normally see it labeled as including or not including a “drug affinity complex” (DAC) that gives the peptide a longer half-life in the body.
On top of the general positive health benefits of HGH described earlier, CJC-1295 can also:
Make your sleep deeper
Accelerate your body’s ability to heal wounds and injuries
Increase energy levels
Restore insulin sensitivity
If you’re looking to improve your body composition while optimizing metabolic health and heart health, CJC-1295 should be your choice and used alongside Ipamorelin.
Continuing the discussion of HGH, Ipamorelin is a GHRP that differs greatly from other molecules in its class (Hexarelin, GHRP-2, etc.).
It ONLY targets HGH production/release and does not elevate the production of other hormones such as cortisol and prolactin, both of which reduce the breakdown of fat tissue at high levels.
Ipamorelin also does not touch the hunger hormone ghrelin, meaning your level of hunger will be reduced… an absolute must if you are taking on a challenging intermittent fasting protocol such as Guaranteed Shredded.
This peptide shares many of the positive health benefits as CJC-1295 for obvious reasons, but other notable outcomes of Ipamorelin use include:
Better gut health
Favorable effects on cognitive health
Accelerated fat loss
Decreased joint and muscle pain
Enhanced workout recovery
While Ipamorelin can be used alone as an excellent sleep-inducing and fat loss agent, I stand by my prior to recommendation to combine it with CJC-1295 for best results.
Epitalon is a derivative of Epithalamin, a naturally-produced peptide found in your pineal gland.
Discovered in the 1980s by Russian scientists and popularized by Dr. Vladmir Khavinson as a “bioregulator” to possibly prevent premature aging in Russia’s military men.
(NOTE: A peptide bioregulator is a peptide that can “communicate with their specific section of the DNA, activating genes for cellular regeneration” and can function as “a cellular mediator to regulate gene expression and protein synthesis”)
It primarily works by increasing production of an enzyme called telomerase, which allows our cells to produce protective parts of our DNA called telomeres… which themselves allow DNA to replicate and lead to the production of new cells.
Long story short, our body’s production of telomerase decreases over time and this results in shorter telomeres.
Consequently, this means cells will eventually be unable to divide and these diseased cells cannot be replaced… leading to our eventual death.
So with longer telomeres and higher telomerase production, the natural outcome should be life extension and by extension a lower biological age.
In several human and animal studies conducted by the Russians, Epitalon supplementation led to lower mortality and overall higher survival amongst the elderly and frail.
But even in healthy people, Epitalon can be used to improve the quality of your sleep by increasing the body’s natural production of the sleep hormone melatonin.
Other possible benefits include better cardiovascular health, improved carbohydrate metabolism, and lowering age-associated impairment of physical endurance.
If your goal of living a much longer life supersedes that of maintaining physical appearance, Epitalon is the anti-aging peptide injection you want to be taking.
Thymalin is a peptide spanning 9 amino acids that is naturally produced in your thymus gland.
Your thymus gland is responsible for regulating the body’s immunity by allowing it to differentiate between naturally-produced compounds and foreign substances entering your body.
But since this gland “ages” faster than every other organ in your body, the thymus gland gradually decreases in both size and its ability to maintain a robust immune system.
Although Thymalin was discovered in the 1970s by a French scientist, it was the Russian scientists in the 1980s who sought to use the peptide as a bioregulator to restore size and function to the thymus gland in older individuals.
(Because as it turns out, Thymalin production also lowers with age).
Thymalin primarily works through “T-cell differentiation and enhancement of T and NK cell actions” (Source), both of which are key parts of the body’s immune response.
While the role of this peptide as an immunity booster is crystal clear, the Russians also discovered Thymalin extends lifespan just like Epitalon does.
And when you combine the two peptides together, you get a much lower mortality rate compared to using either peptide alone.
Other benefits observed include lower incidences of respiratory and cardiovascular disease, excellent anti-inflammatory properties, and potential anti-tumor activity.
Thymalin is the peptide you want to use if you want to keep your immune system fully functioning at an older age, but for life extension purposes you’ll definitely want to use it alongside Epitalon.
Do Peptides Help Sagging Skin and Wrinkles?
Now that we’ve talked about the best injectable peptides for anti-aging, let’s move on to the injectable peptides for skin tightening.
Fundamentally, the goal of reducing wrinkle formation and sagging of skin is to increase the production of two proteins: Collagen and elastin.
“Collagen is a protein found naturally in our skin, especially in connective, fibrous and supportive tissue. Collagen is the protein that is found in the largest amount in the human body. 30% of the proteins in the human body are of the collagenic kind.”
“Elastin is a protein produced by fibroblasts that can create a network of elastic fibers (five times more stretchable than a rubber band of the same diameter). These elastin fibers are responsible for the elasticity of the skin… Elastin fibers account only for 5-10% of the total dermal fiber”
Both proteins are susceptible to lower production because of unhealthy lifestyle choices: Sleep deprivation, smoking, excess sugar consumption, weight gain, dehydrate, chronic exposure to sunlight, etc.
However, despite their similarities as important structural components of your skin, there are some important differences:
The best injectable peptides for anti-aging and skin tightening allow you to look younger, feel younger and live a longer life free of disease.
You’ll find yourself feeling more energetic and far stronger in every way imaginable — almost as if you’ve been given a brand new brain and body to thrive and achieve the type of life you’ve always wanted.
Aging is a natural part of life, but it doesn’t have to be feared or hated.