For many men, turning 50 is a milestone that comes with negatives changes to their health:
- Higher susceptibility to andropause, a reduction in levels of testosterone and other androgens that leads to symptoms such as lower libido, decreased energy and mood swings
- 20% of men 50 years or older experience osteoporosis, with the rate of bone density loss after their 60s being 0.5-1% per year
- Memory and mental sharpness often start to decline in the mid-40s (ex. forgetting names and dates)
- Increased weight gain combined with a decrease in muscle mass
Getting older can feel like a constant uphill battle to maintain your health, but it certainly doesn’t have to be a losing one.
Thanks to the discovery of peptides, you you can delay the onset of aging and start feeling like yourself again.
In this article, we’ll explore how peptides for men over 50 can provide support for muscle growth, help manage weight, and transform their health to become fully optimized!
Understanding How Peptides Work
Peptides are a sequence chains made up of amino acids, with each peptide containing between two and fifty amino acids (not unlike beads on a bracelet).
Due to their smaller size compared to proteins, peptides can be more easily broken down and absorbed by the body.
This makes them highly effective at optimizing various biological processes while being selective for treating certain conditions.
Peptides have been clinically shown to have wide-ranging benefits such as stimulating the release of growth hormone, improving sleep quality and raising energy levels.
In the case of the former, growth hormone release can lead to outcomes like increased muscle growth, faster fat loss, and elevated testosterone levels.
But even though the natural production of peptides in our bodies decline with age, there’s no need to worry.
Peptide therapy has been shown to help men age gracefully and maintain their vitality even when they are past the age of 50.
How Peptide Therapy Can Help Men As They Age
Take a look at the picture below — I AM living positive proof that peptides are absolutely game-changing for men over 50.
They have made a dramatic difference in how quickly I recover from the gym.
And on top of accelerating fat loss in ways I never thought possible, they have also improved my skin health and helped me look many years younger via slowing the aging process.
Athletes, bodybuilders, and even weekend warriors are now just starting to realize the power of peptides… even though I’ve been screaming from the rooftops about them since 2004.
Peptide therapy helps stimulate and regulate MANY bodily functions including immune system response, neurotransmitter activity, and hormone regulation.
Going back to the earlier example of testosterone, it is critical in building muscle mass and preventing/treating hypogonadism.
Men with hypogonadism do not produce enough testosterone, which can result in:
- Infertility
- Erectile dysfunction
- Muscle loss
- Breast tissue development
- Loss of bone mass over time
Fortunately, some peptides can help boost testosterone levels by stimulating the release of luteinizing hormone (LH), gonadotropin-releasing hormone (GnRH), and follicle-stimulating hormone (FSH) — all hormones that are important in producing testosterone in men.
Research even shows these peptides can help increase serum testosterone levels within 24 hours of injection.
Consistent use of said peptides can also help men produce sufficient amounts of GnRH), further boosting their testosterone levels while restoring their fertility.
This is just one of many examples showing the the use of peptide therapy – combined with proper diet and exercise – can be absolutely life-changing for older men seeking the vitality they once had in their younger years.
Best Weight Loss Peptides for Men Over 50
Peptides for weight loss are beneficial for men just as much as they are for women, and below I AM sharing the three best weight loss peptides for men over 50.
AOD-9604
AOD-9604 is a synthetic peptide that helps boost fat metabolism, thereby promoting weight loss in men.
Unlike other fat loss modalities, AOD-9604 stimulates lipolysis (i.e. the breakdown of fat) while inhibiting lipogenesis (i.e. the production of new fat) without any recorded impact on tissue growth or blood sugar.
This makes AOD-9604 one of the most effective and safest weight loss peptides.
Melbourne-based biotechnology company Metabolic Pharmaceuticals Limited reported that obese patients who were given 1 mg of AOD-9604 lost 2.8 kilograms after 12 weeks of administration.
They also had improved cholesterol profiles and impaired glucose tolerance:
“The drug, which stimulates the metabolism of body fat, is the first of its kind in the world. All other obesity drugs artificially reduce appetite or food absorption.
The drug – codenamed AOD9604 – was taken orally once daily by 300 obese patients at five trial sites over a 12-week period. Six doses were used – 0 mg (placebo), 1mg, 5 mg, 10 mg, 20 mg and 30 mg.
The group receiving the 1mg dose lost the most weight, averaging a weight loss over the 12 weeks of 2.8 kilograms, more than triple the weight lost by those on placebo, who lost an average of 0.8 kilograms.
The rate of weight loss was maintained throughout the treatment period, an encouraging trend for expectations of longer-term dosing.
The weight lost by the 1mg group was slightly more than that achieved by the world’s largest-selling prescription obesity medication in similar trials over the same period, without its troublesome side effects.
The trial results also demonstrated a small but consistent improvement in cholesterol profiles and a reduction in the number of patients with impaired glucose tolerance.”
Moreover, AOD-9604 helps with weight loss by changing lipid metabolism in adipose tissue.
This has been shown in a study in rats that lost weight after 30 days of AOD-9604 treatment compared to HCG without any side effects:
“A small synthetic peptide sequence of human growth hormone (hGH), AOD-9401, has lipolytic and antilipogenic activity similar to that of the intact hormone.
Here we report its effect on lipid metabolism in rodent models of obesity and in human adipose tissue to assess its potential as a pharmacological agent for the treatment of human obesity.
C57BL/6J (ob/ob) mice were orally treated with either saline (n = 8) or AOD-9401 (n = 10) for 30 days.
From day 16 onward, body weight gain in AOD-9401-treated animals was significantly lower than that of saline-treated controls.
Food consumption did not differ between the two groups.
Analyses of adipose tissue ex vivo revealed that AOD-9401 significantly reduced lipogenic activity and increased lipolytic activity in this tissue.
Increased catabolism was also reflected in an acute increase in energy expenditure and glucose and fat oxidation in ob/ob mice treated with AOD-9401.
In addition, AOD-9401 increased in vitro lipolytic activity and decreased lipogenic activity in isolated adipose tissue from obese rodents and humans.
Together, these findings indicate that oral administration of AOD-9401 alters lipid metabolism in adipose tissue, resulting in a reduction of weight gain in obese animals.
The marked lipolytic and antilipogenic actions of AOD-9401 in human adipose tissues suggest that this small synthetic hGH peptide has potential in the treatment of human obesity.”
CJC-1295
CJC-1295 aids in weight loss through stimulation of the pituitary gland to release growth hormone, which promotes lean body mass gain and fat metabolism.
It also supports fat oxidation while reducing the storage of body fat.
Combined with an insulin-controlled diet and exercise, CJC-1295 can be a powerful tool for improving overall body composition.
In a study published in the Journal of Hormone Research in Paediatrics, men and women given CJC-1295 for 12 weeks showed increased growth hormone levels, reduced body weight by 1.6 times compared to placebo, and loss of fat in the abdominal area:
“GH treatment caused a 1.6-fold increase in the fraction of body weight lost as fat and a greater loss of visceral fat area than placebo treatment (35.3 vs. 28.5%, p < 0.05)
Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults
We investigated the effects of GH treatment and dietary restriction on lipolytic and anabolic actions, as well as the consequent changes in insulin and GH secretion in obesity.
24 obese subjects (22 women and 2 men; 22–46 years old) were fed a diet of 25 kcal/kg ideal body weight (IBW) with 1.2 g protein/kg IBW daily and were treated with recombinant human GH (n = 12, 0.18 U/kg IBW/week) or placebo (n = 12, vehicle injection) in a 12-week randomized, double-blind and placebo-controlled trial.
GH treatment caused a 1.6-fold increase in the fraction of body weight lost as fat and a greater loss of visceral fat area than placebo treatment (35.3 vs. 28.5%, p < 0.05).
In the placebo group, there was a loss in lean body mass (–2.62 ± 1.51 kg) and a negative nitrogen balance (–4.52 ± 3.51 g/day).
By contrast, the GH group increased in lean body mass (1.13 ± 1.04 kg) and had a positive nitrogen balance (1.81 ± 2.06 g/day). GH injections caused a 1.6-fold increase in IGF-I, despite caloric restriction. GH response to L-dopa stimulation was blunted in all subjects and it was increased after treatment in both groups.
GH treatment did not induce a further increase in insulin levels during an oral glucose tolerance test (OGTT) but significantly decreased free fatty acid (FFA) levels during OGTT.
The decrease in FFA area under the curve during OGTT was positively correlated with visceral fat loss. This study demonstrates that in obese subjects given a hypocaloric diet, GH accelerates body fat loss, exerts anabolic effects and improves GH secretion.
These findings suggest a possible therapeutic role of low-dose GH with caloric restriction for obesity.”
Subcutaneous administration of CJC-1295 can also boost GH levels 2 to 10 fold for 6 days, and IGF-1 levels 1.5 to 3 fold for 9-11 days in test subjects:
The increase in both biomarkers boosted body fat loss loss and improved the participants’ body mass index readings:
“The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 d.
Healthy subjects, ages 21–61 yr, were studied.
CJC-1295 or placebo was administered sc in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study.
After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9–11 d.
The estimated half-life of CJC-1295 was 5.8–8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.
Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 μg/kg.
There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.”
Ipamorelin
One of the benefits of Ipamorelin is that it can suppress appetite, leading to fewer calories consumed and faster loss of body fat.
When paired with an insulin-controlled diet and exercise, Ipamorelin can promote lipolysis (i.e. the process of breaking down fats) in the abdominal area.
A study published in the Journal of Hormone and Metabolic Research even showed that the use of human growth hormone, similar to Ipamorelin, can reduce visceral fat and waist circumference thanks to its ability to boost IGF-1 levels:
“Administration of recombinant human growth hormone (rhGH) in obesity has been known to lead to a decrease in visceral adiposity and an increase in lean body mass.
Most studies have used supraphysiological doses of rhGH, which were administered daily or every other day.
We aimed to evaluate whether weekly administered low dose of sustained-release rhGH (SR-rhGH) could play a therapeutic role in the treatment of abdominal obesity.
Prospective, single-arm, open-label, multicenter pilot study was carried out.
Participants were 26 adults aged 40-65 years old with abdominal obesity (male: waist circumference >90 cm, female: waist circumference >85 cm).
The subjects were given 3 mg of SR-rhGH, administered subcutaneously, weekly for 26 weeks.
SR-rhGH treatment for 26 weeks increased the IGF-1 level by 56.53±76.09 μg/l (SDS 0.77±1.12) compared to the baseline (p=0.0022).
After 26 weeks, SR-rhGH treatment reduced abdominal visceral adipose tissue (VAT) (140.35±75.97 to 128.43±73.85 cm2, p=0.0038).
Average waist circumference decreased from 96.25±6.41 to 91.93±6.13 cm (p<0.0001) after treatment.
However, body weight or lean body mass did not show any significant change.
In conclusion, SR-rhGH treatment for 26 weeks reduced abdominal visceral fat and waist circumference without severe adverse events.”
And just like AOD-9604, Ipamorelin is one of the safest and most effective peptides to help you get back in your best shape without adverse side effects.
However, when comparing Ipamorelin to AOD-9604, make sure you understand their distinct mechanisms and benefits to determine which peptide best aligns with your health and fitness goals.
Best Muscle Growth Peptides for Men Over 50
If you’re looking to pump up your muscle gains in your 50s, the use of peptides for muscle growth may be worth your while.
See which peptides featured below are best suited for your muscle-building goals.
CJC-1295/Ipamorelin Combination
Stacking the peptides Ipamorelin and CJC-1295 together is mainly done by bodybuilders for the purpose of fat loss.
However, some biohackers are convinced the combination can also help promote muscle growth and strength.
Ipamorelin works by enhancing protein synthesis and muscle tissue regeneration after a musculoskeletal injury.
CJC-1295, on the other hand, supports healthy GH levels and this stimulates hypertrophy.
In other words, the CJC-1295 and Ipamorelin stack supports muscle growth while minimizing muscle recovery (even after an intense workout).
For instance 18 elderly men who were given CJC-1295 for 14 weeks reported increased IGF-I levels, better fat loss, and greater muscle mass/strength:
“To investigate whether age-related deficits in the somatotropic axis limit the degree to which muscle strength can improve with resistance training in older individuals, we conducted a double blind, placebo-controlled exercise trial.
Eighteen healthy elderly men (65-82 yr) initially underwent progressive weight training for 14 weeks to invoke a trained state.
Subjects were then randomized to receive either 0.02 mg/kg BW.day recombinant human GH (rhGH) or placebo, given sc, while undertaking a further 10 weeks of strength training.
Sequential measurements were made of muscle strength (one repetition maximum), body composition (dual energy x-ray absorptiometry), and circulating levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3.
For each exercise, strength increased for both groups (P = 0.0001) through 14 weeks of training, with little improvement thereafter.
Increases in muscle strength ranged from 24-62% depending on the muscle group.
Baseline plasma IGF-I concentrations were similar in both groups (mean +/- SEM, 106 +/- 9 micrograms/L), approximately half that observed in healthy young adults.
In the rhGH group, IGF-I levels increased to 255 +/- 32 micrograms/L at week 15 and 218 +/- 21 micrograms/L at week 24 (P < 0.001). In the placebo group, IGF-I increased slightly to 119 +/- 6 micrograms/L at 24 weeks.
IGF-binding protein-3 also increased in the rhGH group (P < 0.05). rhGH had no effect on muscle strength at any time, and no systematic difference in muscle strength was observed between groups throughout the study.
Body weight did not change in either group, but lean body mass increased, and fat mass decreased (P < 0.05) in the rhGH group.”
Sermorelin
Sermorelin, a growth hormone-releasing hormone (GHRH), can help boost the release of growth hormone and insulin-like growth factor 1 (IGF-1) in the body via stimulation of the pituitary gland.
This contributes to bone repair, muscle growth, and fat loss in men.
In a study published in the International Journal of Endocrinology, men between 50 and 70 years old who underwent Sermorelin therapy improved their leg press strength.
This shows that human growth hormone (HGH), such as that produced by stacking Sermorelin and Ipamorelin, can boost muscle strength, especially in the lower body:
“Fourteen healthy men aged 50–70 years were evaluated at baseline for body composition and muscle strength (evaluated by leg press and bench press exercises, which focus primarily on quadriceps—lower body part and pectoralis major—upper body part—muscles, resp.).
Subjects were randomised into 2 groups: GH therapy (7 subjects) and placebo (7 subjects) and reevaluated after 6 months of therapy.
Thirteen subjects completed the study (6 subjects in the placebo group and 7 subjects in the GH group).
Subjects of both groups were not different at baseline. After 6 months of therapy, muscle strength in the bench press responsive muscles did not increase in both groups and showed a statistically significant increase in the leg press responsive muscles in the GH group.
Our study demonstrated an increase in muscle strength in the lower body part after GH therapy in healthy men.”
BPC-157
BPC-157 is an essential peptide for men over 50 due to its ability to speed up the body’s rate of recovery from injuries and wounds.
Apart from BPC-157’s benefits for gut health, the peptide also supports bone and joint health.
In a study published in Bone, BPC-157 helped improve bone mineral density and accelerated the healing of segmental bone defects in rabbits and rats:
“Gastrectomy often results in increased likelihood of osteoporosis, metabolic aberration, and risk of fracture, and there is a need for a gastric peptide with osteogenic activity.
A novel stomach pentadecapeptide, BPC-157, improves wound and fracture healing in rats in addition to having an angiogenic effect.
Therefore, in the present study, using a segmental osteoperiosteal bone defect (0.8 cm, in the middle of the left radius) that remained incompletely healed in all control rabbits for 6 weeks (assessed in 2 week intervals), pentadecapeptide BPC-157 was further studied (either percutaneously given locally [10 μg/kg body weight] into the bone defect, or applied intramuscularly [intermittently, at postoperative days 7, 9, 14, and 16 at 10 μg/kg body weight] or continuously [once per day, postoperative days 7–21 at 10 μg or 10 ng/kg body weight]).
For comparison, rabbits percutaneously received locally autologous bone marrow (2 mL, postoperative day 7).
As standard treatment, immediately after its formation, the bone defect was filled with an autologous cortical graft.
Saline-treated (2 mL intramuscularly [i.m.] and 2 mL locally into the bone defect), injured animals were used as controls.
Pentadecapeptide BPC-157 significantly improved the healing of segmental bone defects.
For instance, upon radiographic assessment, the callus surface, microphotodensitometry, quantitative histomorphometry (10 μg/kg body weight i.m. for 14 days), or quantitative histomorphometry (10 ng/kg body weight i.m. for 14 days) the effect of pentadecapeptide BPC-157 was shown to correspond to improvement after local application of bone marrow or autologous cortical graft.
Moreover, a comparison of the number of animals with unhealed defects (all controls) or healed defects (complete bony continuity across the defect site) showed that besides pentadecapeptide intramuscular application for 14 days (i.e., local application of bone marrow or autologous cortical graft), also following other pentadecapeptide BPC-157 regimens (local application, or intermittent intramuscular administration), the number of animals with healed defect was increased.
Hopefully, in the light of the suggested stomach significance for bone homeostasis, the possible relevance of this pentadecapeptide BPC-157 effect (local or intramuscular effectiveness, lack of unwanted effects) could be a basis for methods of choice in the future management of healing impairment in humans and requires further investigation.”
Similarly, rats with injuries in the Achilles tendon experienced speedier healing after BPC-157 administration, eliminating the need for surgical repair:
“In studies intended to improve the healing of the transected Achilles tendon, effective was a stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419).
Currently, in clinical trials for inflammatory bowel disease (PLD-116, PL 14736, Pliva), it ameliorates internal and external wound healing.
In rats, the right Achilles tendon transected (5 mm proximal to its calcaneal insertion) presents with a large tendon defect between cut ends.
Agents (/kg b.w., i.p., once time daily) (BPC 157 (dissolved in saline, with no carrier addition) (10 microg, 10 ng or 10 pg) or saline (5.0 ml)), were firstly applied at 30 min after surgery, the last application at 24 h before autopsy.
Achilles functional index (AFI) was assessed once time daily.
Biomechanical, microscopical and macroscopical assessment was on day 1, 4, 7, 10 and 14. Controls generally have severely compromised healing.
In comparison, pentadecapeptide BPC 157 fully improves recovery: (i) biomechanically, increased load of failure, load of failure per area and Young’s modulus of elasticity; (ii) functionally, significantly higher AFI-values; (iii) microscopically, more mononuclears and less granulocytes, superior formation of fibroblasts, reticulin and collagen; (iv) macroscopically, smaller size and depth of tendon defect, and subsequently the reestablishment of full tendon integrity.
Likewise, unlike TGF-beta, pentadecapeptide BPC 157, presenting with no effect on the growth of cultured cell of its own, consistently opposed 4-hydroxynonenal (HNE), a negative modulator of the growth. HNE-effect is opposed in both combinations: BPC 157+HNE (HNE growth inhibiting effect reversed into growth stimulation of cultured tendocytes) and HNE+BPC 157 (abolished inhibiting activity of the aldehyde), both in the presence of serum and serum deprived conditions.
In conclusion, these findings, particularly, Achilles tendon transection fully recovered in rats, peptide stability suitable delivery, usefully favor gastric pentadecapeptide BPC 157 in future Achilles tendon therapy.”
Combining Peptides with Lifestyle Changes
Peptide therapy, combined with positive lifestyle habits, can be a powerful tool to help men in their 50s improve athletic performance and and achieve a fully optimized way of living.
For example, eating a balanced diet provides the essential nutrients your body needs to function properly.
Some people find the body’s demand for certain nutrients increases while on peptide therapy, especially the ones involved in muscle growth and repair.
Which means you CANNOT use peptides as a crutch to shove garbage down your mouth.
Make sure to eat meals to fuel the fittest version of you, with each one including…
- Lean proteins to support muscle growth and recovery
- Healthy fats to promote brain health and hormone production
- Complex carbohydrates for sustained energy for workouts and daily activities
- Vitamins and minerals to ensure your body has the necessary components for optimal health
Doing exercise, especially training to positive muscular failure at least 3 times per week, can further enhance muscle growth and boost metabolism.
Getting enough sleep is also important, so aim to get at least 7 hours of deep uninterrupted rest each night.
These habits can help transform your health at any age alongside peptide usage, and even moreso once you reach the big 5-0.
Safety Considerations and Potential Side Effects
Taking peptides is generally safe and do not lead to adverse outcomes (provided you dose them properly).
However, like any medical treatment plan, there are some minor risks and side effects you should know about.
These include…
- Allergic reactions
- Hives
- Swelling
- Breathing difficulties
- Injection site reactions
- Pain
- Swelling
- Bruising at the site of injection
- Hormonal imbalances
Peptides may also interact with other medications you may be taking, so it’s important to inform your doctor about any medicines or supplements you’re using before starting peptide therapy.
Closing Thoughts
Just because you’re getting older doesn’t mean you should give up on getting and staying fully optimized.
Just by using the best muscle growth peptides for men over 50, you can continue to build muscle and maintain your strength well into your later years.
And that’s the tip of the iceberg for just one health goal.
So remember these two things before you finish reading the article…
First, we are all of N-of-1 and our bodies are uniquely different, so make sure you find the peptide regimen that works best for you and your specific goals.
Second, peptide therapy is NOT a magic bullet.
You must an insulin-controlled lifestyle by eating a nutritious diet, exercising regularly, and getting enough rest to support your overall health and wellness.
And a third reminder as a bonus for reading this far:
ALWAYS buy peptides from reputable sources like Limitless Biotech to ensure you’re maximizing the desired results you get from using said peptides.
They have the best formulations of experimental compounds available, and no other vendor comes close to offering them at ultra-high levels of purity for reasonable prices.
Use code JAY15 to get 15% off your order of NON-VIP peptides and 5% off VIP peptides
But even if you aren’t ready to jump on the peptides bandwagon just yet…
Make sure you read the Top 10 Mistakes People Make When Starting Therapeutic Peptides FREE PDF before you place a single order!
Seriously, this short e-book will save you a lot of wasted money and poorly spent time (not to mention preventing you from potential self-inflicted missteps).
And the emails I’ll send you after downloading the book contain EXCLUSIVE 20% OFF discount codes code for all my amazing courses on using therapeutic peptides, such as:
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See you on the other side!
