- Jay's Protocol
Jay Campbell's Fat Loss Protocol
Burn more fat. Control appetite. Keep the muscle you’ve built.
Goal: Aggressive Fat Loss & Metabolic Optimization
- Protocol Overview
This isn’t a protocol for people who want to lose a few pounds by cleaning up their diet.
It’s what serious men and women use when they want to attack body fat from multiple angles at once — suppressing appetite, driving fat oxidation, supporting GH output, and improving the metabolic environment that determines how your body uses and stores energy.
Compounds
6
Protocol Duration
8–12 weeks
Administration
Mixed
Best For
Men and women 30–65, intermediate to advanced
This protocol is for you if:
- You've stalled on diet and training alone and need compounds that move the needle
- You're carrying stubborn fat — particularly visceral — that hasn't responded to conventional approaches
- You want to control hunger without relying on willpower
- You're focused on body recomposition, not just the number on the scale
This protocol is NOT for you if:
-
You're brand new to peptides — start with the
Reconstitution Course first - You haven't had recent bloodwork done
- You're not currently following a structured nutrition and training program
The Compounds
ShredMAX
What It Does: Contains SLU-PP-332, a research-grade ERR receptor agonist that activates all three estrogen-related receptor subtypes — ERRα, ERRβ, and ERRγ. Drives fat oxidation, improves exercise capacity, and supports mitochondrial biogenesis without the cardiovascular risks associated with older stimulant-based fat burners.
Protocol Details:
Dose
1 cap AM + PM
Timing
AM and PM
Frequency
Daily
Duration
Ongoing use
Administration
Capsule
Source
Jay’s Note: ShredMAX is the foundation of this stack. It’s working at the mitochondrial level while the other compounds attack fat from the hormonal and appetite side.
GLP-3 / Retatrutide
What It Does: A triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously. Of everything in the GLP-1 class, this is the most aggressive compound for fat loss — driving appetite suppression, accelerating fat oxidation, and improving multiple metabolic markers at the same time.
Protocol Details:
Dose
0.5mg
Timing
AM
Frequency
3x per week
Duration
8 weeks on, 8 weeks off (or until goal weight reached)
Administration
SubQ injection
Source
Jay’s Note: If you’ve used semaglutide or tirzepatide and want to understand what comes next — this is it. Start conservatively and respect the cycle structure.
BioZapetite
What It Does: An oral GLP-1 receptor agonist (Orforglipron) in capsule form — no injection required. Controls appetite at the central level, reduces caloric intake without hunger crashes, and makes adherence to a caloric deficit significantly easier to sustain day over day.
Protocol Details:
Dose
1 cap AM + PM
Timing
AM and PM
Frequency
Daily
Duration
8–12 weeks on, equal time off
Administration
Capsule
Source
Jay’s Note: BioZapetite stacks directly with GLP-3 for those who want injectable and oral GLP-1 activity running together. If you’re only using one GLP-1 compound, this is the lower-barrier entry point.
Tesamorelin or Ipamorelin
What It Does: Both are growth hormone secretagogues that support fat loss by stimulating the pituitary to release more GH naturally. Tesamorelin is the stronger option for visceral fat reduction and is the compound with the most clinical data behind it. Ipamorelin is milder, well-tolerated, and the better choice if you’re newer to GH peptides or want to run a less aggressive stack. Pick one — not both.
Tesamorelin Protocol Details:
Dose
1mg
Timing
AM or PM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Ipamorelin Protocol Details:
Dose
300mcg
Timing
AM or PM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: I run Tesamorelin. It’s the most well-researched GHRH analog for visceral fat, and if stubborn abdominal fat is the primary target, there’s nothing else in this class that compares.
Metabolic Blend (NAD+ / MOTS-C / 5-Amino-1MQ)
What It Does: A three-compound injectable blend targeting mitochondrial function, insulin sensitivity, and NNMT inhibition simultaneously. Works at the cellular level to shift your metabolism toward fat oxidation — improving how your body handles glucose, generates energy, and responds to the other compounds in this stack.
Protocol Details:
Dose
500mcg / 1mg
Timing
AM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: Most people running a fat loss protocol focus entirely on appetite and calories. This blend addresses the underlying metabolic dysfunction that makes fat loss hard in the first place.
MOTS-C
What It Does: A mitochondrial-derived peptide that activates AMPK and improves insulin sensitivity. Mimics the metabolic effects of exercise at the cellular level, making it useful for improving glucose handling and body composition — and particularly effective for those whose metabolism has slowed due to age or years of suboptimal diet and training.
Protocol Details:
Dose
1mg
Timing
AM
Frequency
5 days on, 2 days off
Duration
8 weeks on, 8 weeks off
Administration
SubQ injection
Source
Jay’s Note: MOTS-C and the Metabolic Blend overlap in their mechanisms intentionally. You want multiple pathways hitting mitochondrial function and insulin sensitivity at the same time — that’s what separates a real fat loss protocol from just running a GLP-1 and hoping for the best.
How to Run This Protocol
01
Before You Start:
- Get bloodwork done. You need a baseline before you add anything to your system.
- Without it, you're guessing — and guessing is how people miss what's working and ignore what isn't.
02
Running the Stack:
- Follow each compound's individual cycle timing exactly as written.
- Don't compress the off-weeks and don't extend the on-weeks because you're feeling good.
- The cycle structure isn't arbitrary — it's how you maintain receptor sensitivity and keep the compounds working the way they're supposed to.
03
What to Track:
- Run follow-up bloodwork at the six-week mark and again at protocol completion.
- Track your numbers alongside how you actually feel — energy, sleep quality, recovery between sessions, and body composition changes.
04
Common Mistakes:
- Starting without a baseline. If you don't know where you started, you can't know what moved.
- Abandoning the protocol too early. Most of these compounds need four to six weeks before you feel the full effect.
- Skipping the off-weeks. The off-weeks are part of the protocol.
Frequently Asked Questions
Can I run this protocol while on TRT?
Yes — and for most men, TRT is the foundation this stack is built on top of.
Optimized testosterone supports lean mass preservation during a fat loss phase, which matters because the GLP-1 compounds in this stack will reduce appetite and caloric intake significantly.
Run your TRT protocol as normal and layer these compounds on top.
Get bloodwork at the 6-week mark to confirm estradiol, IGF-1, and testosterone levels are tracking where you want them.
Do I need to cycle off?
Yes.
Follow the individual cycle guidelines for each compound.
GLP-3/Retatrutide runs 8 weeks on and 8 weeks off, or until goal weight is reached.
Tesamorelin or Ipamorelin run 8 weeks on and 8 weeks off.
MOTS-C and the Metabolic Blend run 8 weeks on and 8 weeks off.
BioZapetite runs 8–12 weeks on with equal time off.
Your body needs the off-periods to consolidate results and maintain receptor sensitivity.
What if I'm a peptide beginner?
If you haven’t reconstituted or injected peptides before, start with the Reconstitution Course. It covers everything you need to do this safely.
Come back to this stack once you’ve run a simpler protocol first.
Get Fully Optimized with Jay
Quantum Peptides Course
The full protocol education: stacking, timing, and how to optimize every compound in this guide.
$499/one -time
The Ultimate GLP-1 Masterclass
Everything you need to know about running GLP-1 peptides correctly — dosing, muscle preservation, hormone integration, and what your prescribing doctor won’t tell you.
$299
FOH Private Membership
Weekly live coaching calls with Jay. Ask him directly about your protocol, bloodwork, and results.