[Disclaimer: While I always try to provide accurate information based on clinical research, remember that this article is for educational purposes only. Everyone’s body is different, so always chat with your healthcare provider before starting any new supplement regimen!]
After writing so extensively about virtually every peptide in existence, I’ve discovered a brand new class of therapeutic peptides that are mostly obscured from the west.
One hidden away from the Western hemisphere but very much popular in the motherland of Russia.
They’re known as peptide bioregulators and to this day you won’t hear about them unless you’re “in the know”.
As you’ll soon find out, they are very different from mainstream-type medications, hormones, anaesthetics, and even common injectable peptides such as BPC-157 and TB-500.
And due to their unique mechanism of action, these “bioregulators” can even be combined with traditional peptides for an unbelievably synergistic effect.
Keep reading and you’ll see why I’m excited about what the future has in store for peptide bioregulators!
What Are Peptide Bioregulators?
In order to explain what peptide bioregulators are, we need to set in stone some very hard definitions.
There are too many articles on the Internet that do not very clearly differentiate between peptides and peptide bioregulators.
While peptide bioregulators are technically peptides, they are very distinct from traditional peptides and therefore the two terms cannot be used interchangeably.
Let’s go over the differences that demonstrate why bioregulators are their own unique class of peptides…
Method of Administration
When you hear me or anybody in the Western hemisphere use the word “peptide”, we are referring to an injectable bioactive peptide (or sublingual/intranasal for select peptides).
Keep in mind this does not necessarily mean a given peptide is a bioregulator, especially when you are using technical language:
- Peptide: A molecule formed by the linking together of two or more amino acids (up to 50)
- Polypeptide: A string of more than 50 amino acids linked together
- Protein: Two or more polypeptide chains linked together for a specific function
- Bioregulator: Chemical compounds produced by cells in one part of an organism that have profound regulatory effects on biological processes within the organism
In the Eastern hemisphere, specifically the Middle East and Russia, when they use the word “peptide” they are including both bioregulators and traditional peptides such as BPC-157.
HOWEVER… in the context of peptide bioregulators specifically, they are distinct from normal peptides in they are orally active and taken in the form of a capsule/tablet.
This is crucial because any “peptide” commonly known in Western culture has zero functional oral activity and will get completely destroyed by the stomach:
“Since proteins are an important part of the diet, the stomach and intestines harbor countless enzymes that break peptide bonds.
No medication based on unmodified peptides would have a chance to survive the passage through the gastrointestinal tract.
Yet even when appropriately modified peptide compounds make it through the stomach intact, another hurdle awaits them: The cells of the intestinal walls prevent their absorption into the blood.
That is why these kinds of active agents are generally only be administered by injection.”
There are two reasons why peptide bioregulators are only available in oral formulation within Russia…
- Keeping peptide bioregulators as capsules/tablets allowed manufacturers to label them as “supplements” and avoid unnecessary regulatory hurdles*
- For whatever mechanistic reason related to molecular similarity and your body “knowing” what to do with them, peptide bioregulators just happen to be orally active*
*Bioregulators may get metabolized to some degree in the stomach, but not completely and enough gets shuttled to the relevant part of your body for them to be effective.
Selectivity
While traditional peptides tend to almost always be systemic (i.e. affecting the entire body), peptide bioregulators are systems-specific.
In other words, bioregulators are naturally selective and will get shuttled to their associated organ instead of going everywhere in the body (more on that later).
Almost nobody understands the difference unless they use and study both classes of peptides.
This is why I’m going out of my why to make these differences very clear to everyone who reads this article.
Speed of Action
Traditional peptides such as GHK-Cu will have a fairly rapid observable effect and it won’t take long for you notice changes.
Peptide bioregulators are the opposite: Excluding exceptions, you will see results over no sooner than 4 weeks and there are no rapid observable effects.
Due to requiring sustained use for an extended period of time to see significant benefits, you must “start low and go slow” with your dosage while exercising patience.
History & Availability
Unlike traditional peptides that have an entire century of history and discovery stories ranging from all around the world, the history of peptide bioregulators is exclusively limited to the boundaries of Russia:
“…the first peptide bioregulators were developed back in the 70’s of the last century in the Military Medical Academy named after Kirov, and then at the St. Petersburg Institute of Bioregulation and Gerontology the scientists continued their study and the creation of new peptide drugs.
All peptide bioregulators are patented in the Russian Federation and in the leading countries of Europe and the USA (more than 200 patents).”
The bioregulators are largely the brainchild of Dr. Vladmir Khavinson, who you may remember was responsible for spearheading the research into the life-extension properties of Epitalon and Thymalin.
For that reason, you may seem some people refer to this specific group of peptides as “Khavinson bioregulators”.
It also explains why peptide bioregulators are relatively unheard of in the West.
The Russians have patent protection on all their development work and their research is very closed off to the outside world (unless you can fluently read and speak Russian).
Not to mention the makeup of peptide bioregulators, as you’ll see later, means they cannot be easily commercialized by Big Pharma companies.
How Do Peptide Bioregulators Work?
Now that we understand what peptide bioregulators are and what they are not, let’s dig deeper and describe how they work.
As the name implies, bioregulators are natural substances in our body that attempt to return our systems back to a healthy state of biological equilibrium.
They participate in tissue repair by interacting with our cellular DNA directly and accelerating the process of protein synthesis:
“…cells produce low-molecular-weight compounds of a peptide nature, which provide the intercellular transfer of certain information encoded in the amino acid sequence and conformational modifications, thus regulating proliferation, differentiation, and intercellular interactions”
“… bioregulators participate in the regulation of gene expression and protein synthesis. This fact is in accordance with the concept of the regulation of cascade peptide of physiological functions of the organism”
“Short peptides are able to interact with DNA regions and thus affect the genome condition and consequently the synthesis of certain proteins, including those that control the physiological functions of the organism”
While a healthy biological system will work to increase endogenous levels of peptide bioregulators over time, they are much like naturally-produced traditional peptides in their production decreases with age and/or inflammation and disease.
Which is why the logical approach is to re-introduce these peptide bioregulators through an outside source.
But if you recall what I said earlier, the selective nature of peptide bioregulators means they will ONLY restore biological function/activity from the same organ they were originally extracted from.
In other words, you can’t use bioregulators from your cartilage to restore cells in your retina!
So you need to be intentional and purposeful when you are ingesting them.
Types of Peptide Bioregulators
You’ll find three main types of peptide bioregulators with unique characteristics and benefits.Â
Let’s explore each one in detail:
1. Cytamins: The Natural Complex
Cytamins are your most natural option, coming directly from cattle organs.
Think of them as nature’s complete package – they’re not just peptides but a rich mixture of nucleoproteins (proteins that work with DNA), amino acids, and vitamins.
What makes cytamins special is their gentle approach.
Unlike synthetic options, they work gradually in your body, which means you’ll experience more sustainable results over time.
These are often recommended for first-time users or those who prefer a more natural approach to their health regimen.
2. Cytomaxes: The Pure Extracts
Cytomaxes take things a step further.
Instead of using the whole organ extract, scientists isolate just the peptide fractions – the active ingredients that do the heavy lifting.
Key benefits of Cytomaxes include:
- More concentrated effects than Cytamins
- Faster results due to higher purity
- Better absorption by your body
- More predictable outcomes
Cytomaxes are basically the refined version of Cytamins, like comparing fresh-squeezed orange juice to eating a whole orange.
3. Cytogens: The Lab-Created Option
These are the newest kids on the block, created in laboratories through advanced synthesis methods.
Scientists study the most effective parts of natural peptides and recreate them precisely, usually as three-amino-acid compounds.
Your body responds to Cytogens differently than natural options:
- They work faster than natural variants
- Effects are typically stronger
- Results may not last as long
- Often used as “starter” treatments
Dr. Vladimir Khavinson pioneered these compounds in the 1970s and found that each type works by matching up with specific parts of your DNA – like a key fitting into a lock.
This explains why they only affect the organs they’re designed for, making them incredibly targeted in their approach.
The most interesting part? All these types can work together.
Many doctors recommend starting with Cytogens for quick results, then switching to natural options like Cytamins for long-term maintenance.
This gives you the best of both worlds – immediate benefits and lasting results.
Who Are Peptide Bioregulators Recommended For?
Peptide bioregulators are particularly recommended for:
- People over 30 years old seeking preventive health measures
- City dwellers exposed to environmental pollutants
- Individuals living in high-stress environments
- Those interested in healthy aging support
- Office workers with sedentary lifestyles
- Athletes and active individuals
Research from the St. Petersburg Institute of Bioregulation and Gerontology suggests that these compounds become increasingly relevant with age as our natural peptide production decreases.
They are especially useful for supporting:
- Your immune system function
- Cardiovascular health
- Hormone balance
- Brain function
- Bone density
After two decades of using peptides therapeutically and helping thousands optimize their health, I’ve seen firsthand how transformative proper peptide therapy can be.
But I also understand it can feel overwhelming when starting.
Want to dive deeper? For a comprehensive overview, check out my international bestseller, “Optimize Your Health with Therapeutic Peptides.”
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Peptide Bioregulator Examples
Before I explore the many ways in which peptide bioregulators can fully optimize your health, there are a few caveats I need to disclose.
First, 99% of the published research comes directly from Khavinson himself or a closely associated researcher.Â
This isn’t to crap on the phenomenal work the Russians are doing, but the fact remains that these compounds need independent clinical trials and replication of their promised results on an (ideally) international level to validate their safety and efficacy.
As much as I like to harp on America’s “sick care system”, we have the money and the manpower to run our own research and fully test these peptide bioregulators for ourselves.
All supposed effects are speculative due to the majority of positive data coming from the anecdotal testimonials of biohackers and ordinary people.
Second, there are way too many peptide bioregulators for me to cover due to their selective nature.
Just take a look at how many of them this Russian vendor is selling — I’d end up writing a book if I wrote about each and every one of them.
Testes, thyroid, muscles, heart, bladder, retina, pancreas… if there’s an organ system in your body, there is one or more bioregulators for it.
So with those two things in mind, I’m going to cover ten peptide bioregulators I found interesting.
All of the information below is taken directly from a book called The Peptide Bioregulator Revolution, a very dense 58-page book that will tell you way more about bioregulators than I ever could.
Just consider this as a fraction of what is possible with these Golden Age compounds!
1. Thyroid Peptide Bioregulator (Thyreogen)
Thyroid health is crucial for overall well-being, and Thyreogen works specifically to support this vital gland.
What makes this bioregulator special is its ability to balance both overactive and underactive thyroid conditions—something that’s quite rare in therapeutic compounds.
Thyreogen has shown particular effectiveness for:
- Supporting thyroid function in people over 50
- Helping with thyroid nodules
- Addressing iodine deficiency issues
- Normalizing thyroid hormone production
Combined with Ventfort bioregulator (a blood vessel bioregulator), you may see significant improvement in thyroid function markers within 3-6 months of treatment.
2. Thymus Bioregulator (Timalin)
Timalin stands out in Khavinson’s research as a fundamental immune system regulator.Â
Isolated from animal thymus tissue, this polypeptide preparation has shown good clinical efficacy across multiple studies.
A comprehensive study of 106 coronary artery disease patients (average age 69) showed impressive results:
- 14% increase in physical exercise capacity after first course
- 53% of patients showed improved oxygen consumption
- Significant reduction in cholesterol levels
- The mortality rate of only 6.6% compared to 13.6% in the control group
Even more interesting is Timalin’s use in preventive medicine.
As mentioned in Khavinson’s research, in a study of people aged 70-88 years with frequent inflammatory conditions, regular Timalin courses led to:
- Enhanced T-lymphocyte functional activity
- Normalized blood coagulation
- Reduced frequency of acute respiratory infections
- Improved overall muscle tone
3. Brain Bioregulator (Cerluten)
Cerluten might be what you’re looking for to support your brain health and cognitive function.
Created from carefully extracted young animal brain tissue, this bioregulator specifically targets neural tissue health and function.
It may:
- Enhance your cognitive performance
- Help you concentrate better
- Reduce brain fog symptoms
- Improve memory function
The recommended protocol is straightforward: take two capsules daily for one month, followed by another cycle 3-6 months later.
Cortexin, isolated from the cerebral cortex, also shows particular promise in supporting brain function.
Khavinson’s research also suggests that in a comprehensive clinical trial of 272 patients aged 30-80 with ischemic stroke, there were significant improvements when treated with Cortexin.
Key clinical findings include:
- Faster recovery of daily activities
- Enhanced cognitive function restoration
- Improved neurological outcomes
What makes Cortexin particularly noteworthy is its effectiveness across age groups.Â
In another study of 250 patients aged 50-70 with various types of encephalopathy (also mentioned in his research), the treatment led to clear normalization of brain bioelectrical activity and improved intellectual functions.
4. Retina Bioregulator (Retinalamin)
If you’re concerned about age-related vision changes, Retinalamin’s clinical data is particularly compelling.Â
This bioregulator, developed from retinal tissue, has successfully treated various eye conditions.
Khavinson’s research also mentions a study involving 700 patients (72% elderly), where Retinalamin showed:
- 2.5 times better visual acuity maintenance over 10 years compared to control groups
- Significant improvement in macular degeneration cases
- Enhanced antioxidant activity in both blood and tears
- Protection against vision deterioration in diabetic conditions
The treatment protocol typically involves parabulbar administration, with results showing that patients receiving regular Retinalamin courses maintained stable vision.
At the same time, control groups experienced up to 57% decline in visual acuity over 10 years.
5. Prostate Peptide Bioregulator (Prostatilen)
This bioregulator addresses one of the most common men’s health concerns – prostate function.
Clinical studies involving 307 patients showed awesome results: within 6 months of treatment, 96.7% experienced complete resolution of prostate-related symptoms.
In studies conducted at the Military Medical Academy, Prostatilen worked by:
- Reducing prostate inflammation and swelling
- Improving urinary function
- Supporting overall prostate health
- Normalizing prostate secretion
The research showed clinical improvement in 53.5% of men with benign prostatic hyperplasia (BPH)—quite significant for a natural compound.
6. Liver Peptide Bioregulator (Svetinorm)
Your liver is your body’s primary detoxification organ, and Svetinorm helps optimize its function.
This bioregulator supports multiple liver functions:
- Better fat metabolism
- Enhanced detoxification capacity
- Improved blood clotting regulation
- Protection against environmental toxins
Svetinorm also helps normalize liver enzyme levels. You may see significant improvements in ALT and AST levels within 2-3 months of treatment.
7. Muscle Bioregulator (Gotratix)
Especially valuable for aging individuals and athletes, Gotratix represents a unique innovation in muscle support.Â
This bioregulator is derived from a specialized mixture of peptides extracted from young animals’ tricep muscles. It takes a targeted approach to muscle health.
Gotratix works through several key mechanisms to enhance your muscle function:
- Optimizes muscle metabolism at the cellular level
- Improves how your muscles adapt to exercise
- Significantly reduces recovery time between workouts
- Helps maintain muscle mass during aging
You may see impressive results in preventing age-related muscle wasting (sarcopenia) and maintaining more muscle mass.
8. Pineal Bioregulator (Epithalamin)
Did you know you can naturally support your sleep-wake cycles and aging process? Epithalamin is the answer.Â
This bioregulator works with your pineal gland, which is often called the “third eye” for its role in regulating circadian rhythms and biological aging.
Groundbreaking research by Professor Vladimir Khavinson showed remarkable results in elderly patients.
In a 15-year clinical study involving 46 elderly patients with coronary artery disease, Epithalamin showed:
- Significant improvement in melatonin production
- Enhanced sleep quality
- Better cognitive function
- Reduced biological age markers
Epithalamin is more special for its long-term effects.
Clinical studies have found that after just one course of treatment (10 days), benefits can last 4-6 months.
Even more impressive, patients receiving regular courses of Epithalamin showed a 37.5% lower mortality rate compared to control groups after 12 years.
9. Kidney Bioregulator (Pielotax)
Pielotax helps support your kidney – a vital organ that filters your blood and maintains electrolyte balance.
Clinical effects include:
- Enhanced kidney filtration capacity
- Better electrolyte balance
- Improved toxin removal
- Normalized kidney function markers
The effects become even more pronounced when combined with another bioregulator called Chitomur (which targets the bladder).
10. Vascular Bioregulator (Vesugen)
Your cardiovascular system is literally your lifeline, and Vesugen works specifically to support it.
Unlike naturally derived bioregulators, Vesugen is a synthetically created tripeptide composed of three amino acids: lysine, glutamine, and asparagine.
This precise composition allows for targeted vascular support.
Research shows multiple benefits:
- Supports overall heart health
- Improves blood vessel function
- Helps regulate blood lipid levels
- Enhances circulation throughout the body
But it doesn’t just benefit your cardiovascular system. By improving blood circulation in capillaries, it can also enhance your skin metabolism and overall skin health.
Vesugen also helps reduce levels of very low-density lipoproteins (VLDL), troublesome blood fats that can contribute to cardiovascular issues.
This makes it particularly valuable for anyone concerned about maintaining healthy cholesterol levels and heart health.
How to Take Peptide Bioregulators
Peptide bioregulators come in capsules taken orally, typically twice daily.
An intensive one-month course helps saturate tissues, while follow-up 10-day quarterly maintenance courses preserve the benefits.
Here is the generally recommended protocol:
For Prevention (Age 35+):
- 2-3 courses per year
- 10-day duration per course
- 2 capsules daily
For Treatment (Age 40+):
- 2 courses per year
- 30-day duration per course
- 2 capsules daily
- Take 30 minutes before meals
For Maintenance (Age 50+):
- 3 courses per year
- 30-day duration per course
- 2 capsules daily
Most protocols start with synthetic versions for the initial intensive course and then switch to natural versions for maintenance.
It’s best to take them on an empty stomach 30 minutes before meals.
By the way, if you’re as fascinated by these compounds as I am, you’ll love my recent conversation with Phil Micans.
In our podcast “Bioregulators: The Sick Care Killers They Don’t Want You to Know About,” we explain why these peptides are revolutionary and not widely known in conventional medicine.
It’s an eye-opener you won’t want to miss!
Peptide Bioregulator Side Effects
Extensive clinical studies spanning 30 years involving more than 15 million people have shown that peptide bioregulators demonstrate remarkably few side effects.Â
However, note these reported minimal side effects:
- Temporary digestive adjustment
- Mild headaches during initial use
- Slight changes in sleep patterns
Contraindications include:
- Pregnancy and breastfeeding
- Individual component intolerance
- Acute inflammatory conditions
- Severe liver or kidney dysfunction
Frequently Asked Questions (FAQs)
Let’s address some common questions about peptide bioregulators.
Are Peptide Bioregulators Safe for Long-Term Use?
Yes. Peptide bioregulators are safe for long-term use. Unlike hormones, they don’t create dependency or suppress natural peptide production.Â
Clinical observations over 30+ years have shown no significant adverse effects from prolonged use.
Do Peptide Bioregulators Require a Prescription?
In most countries, peptide bioregulators are classified as dietary supplements and don’t require a prescription.
However, it’s always recommended to consult a healthcare provider before starting any new supplement regimen.
Can I Take Peptide Bioregulators If I Have a Pre-Existing Health Condition?
Unless you have an intolerance, peptide bioregulators are quite safe. They improve many health conditions.Â
That said, it’s wise to discuss using peptide bioregulators with your doctor if you have significant diseases to ensure there are no contraindications to your treatment plan.
What Are the Common Misconceptions About Peptide Bioregulators?
Common myths include:
- They are the same as injectable peptides (they’re not)
- They get destroyed in the stomach (they maintain their structure)
- They can cause hormonal imbalances (they don’t affect hormone production)
- They require lifelong use (they can be used cyclically)
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Conclusion
That about wraps up everything important you could want to know about peptide bioregulators.
If you really want to dig much deeper into this topic, Dr. Bill Lawrence is clearly the USA’s leading researcher on bioregulators.Â
He is a longevity researcher in the midst of a 3-year trial using bioregulator peptides to see how they influence biological age vs chronological age.Â
This is understood by measuring telomeres and also measuring DNA methylation using the Horvath DNA methylation clock.
I highly recommend viewing this two-part podcast Natalie Niddam did with Dr. Bill Lawrence to gain a much greater understanding of the subject (Bioregulator Peptides and Longevity Research, Part 1 and Part 2).
But as with any peptides-based therapy you use, maximizing any health benefits you hope to achieve first involves addressing the underlying cause of your problem.
Not to mention that the effects of any peptide bioregulator will be less obvious if you are not fully optimized, so make sure your expectations are appropriately set.
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As always…
Raise Your Vibration To Optimize Your Love Creation!
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