Written by Jay Campbell
[Disclaimer: This article is for educational purposes only. Always consult with a qualified healthcare provider before starting any peptide protocol.]
Everyone wants to know about the “dangerous” SLU-PP-332 side effects.
Here’s the truth: I’ve been using SLOOP (as I affectionately call it) personally, and so has Monica.
We did a photoshoot without any prep whatsoever, no diuretics, no carb depletion, no water restriction… and we both appeared in the leanest and most muscular condition of our lives (at 53 years young).
The muscle separation in my chest and biceps, and the striations in my deltoids and obliques, were like nothing I’ve personally EVER achieved.
And I say this as someone who has been at sub-10% body fat many times in the past.
So let me cut through the fear-mongering and give you the actual data, combined with real-world experience from myself and the biohackers in our Fully Optimized Health community, so you can make an informed decision about what I believe is the greatest fat loss compound ever created.
Quick Takeaways
- Preclinical mouse studies involving up to 28 days of SLU-PP-332 use show no liver, kidney, or cardiac toxicity and no severe adverse effects
- The compound works by activating estrogen-related receptors (ERRs) to increase fat oxidation and energy expenditure without stimulant effects
- I personally use SLU-PP-332 and consider it far superior to any fat loss agent I’ve ever used, including Albuterol, Yohimbine, Cardarine, and GW0742
- Practical considerations include sourcing from reputable suppliers, cycling properly, and supporting your mitochondria when you’re not using SLU-PP-332
How SLU-PP-332 Works (The Mechanism You Need to Understand)
SLU-PP-332 is a potent agonist of three estrogen-related receptors (ERRs): ERRα, ERRβ, and ERRγ.
Despite the name, these receptors have NOTHING to do with estrogen signaling.
They regulate metabolic pathways that control how your body produces and uses energy, mimicking many of the metabolic adaptations you’d get from endurance exercise.
If you’ve been following my coverage of MOTS-C, the concept of an exercise mimetic should already be familiar to you.
SLU-PP-332 approaches the same problem from a completely different biological pathway, and in my experience, it’s significantly more powerful.
When you activate ERRs with SLU-PP-332, you shift fuel utilization toward fatty acids and away from carbohydrates.
Within 2 hours of dosing in mice, the respiratory exchange ratio (RER) drops, indicating a rapid switch to burning fat for fuel.
And this effect isn’t a one-time spike either.
Studies show this metabolic shift is sustained over 28 days of continuous dosing.
In practical terms, you’re forcing your mitochondria to ramp up fatty acid oxidation and increase resting energy expenditure by approximately 25% without changing activity levels.
From my direct experience, the real-world effect is even more dramatic than what the mouse data suggests.
I walk around fully fed and hydrated with a more dried out, saran-wrapped look than I’ve ever had before.
What the Preclinical Data Actually Shows
So far, the preclinical data on SLU-PP-332 is impressive.
In healthy, chow-fed mice dosed at 50 mg/kg intraperitoneally twice daily for 28 days, researchers found no change in total body weight, food intake, lean mass, locomotor activity, or white adipocyte size.
No increases in liver enzymes, and minor changes in plasma cholesterol levels that were not classified as adverse.
No liver, kidney, or cardiac toxicity reported.
In obese mice (both diet-induced obese and ob/ob genetic models), the story gets even more compelling.
28 days of SLU-PP-332 reduced body weight by approximately 12%, slashed fat mass gain by over 90%, and dropped plasma cholesterol, HDL, triglycerides, fasting glucose, and insulin.
Most importantly, there was no lean mass loss.
Obese mice supplemented with SLU-PP-332 twice daily lost significant body weight without exercise… and this happened in the presence of excess calories that normally kept them obese.
The compound also reduced hepatic steatosis (fatty liver) and improved glucose tolerance without affecting insulin tolerance or hepatic gluconeogenesis.
If you really want your mind blown, all of this happened without changes in food intake or activity levels!
So where are the horrifying side effects everyone’s worried about?
They’re not in the published data, and they’re definitely not showing up in the real-world biohacker community either.
What I’ve Personally Experienced (And What Our Community Reports)
I’ve personally been using SLU-PP-332 for almost two years and I can tell you this: As of right now, I would argue SLOOP is far superior to any fat loss agent I’ve used previously.
It’s better than any fat loss supplement taken before fasted cardio such as Albuterol, Yohimbine/Rauwolscine, Cardarine, and GW0742.
I do notice hot flashes after my afternoon dose, even when not training, so that’s something you should be prepared for.
But have no fear — this is the compound doing its job, ramping up your metabolic furnace and increasing thermogenesis.
Monica is also using it with incredible results.
In my opinion, there is nothing like this product in the marketplace, and the results we’re seeing in my Fully Optimized Health community are consistently impressive.
For those of you who understand how 5-Amino 1MQ works by inhibiting NNMT to shift metabolism toward fat oxidation, SLU-PP-332 achieves a similar metabolic outcome through an entirely different receptor system albeit with dramatically more noticeable effects on body composition.
Practical Considerations for Safe Use
Here’s what you must know to use SLU-PP-332 intelligently.
Sourcing Matters More Than Anything
If you’re buying SLU-PP-332 from a random underground research chemical supplier, you have ZERO assurance of purity, accurate dosing, or absence of contamination.
This is why I specifically recommend BioLongevity Labs’ ShredMAX, which doses SLU-PP-332 at 100mg per capsule and is produced to the standards I trust.
Source quality can be the difference between life-changing results and wasting your money on garbage.
Cycling Is Essential
Over time, your body will build up a tolerance to SLU-PP-332 and treat it as a foreign object it wants to get rid of.
There will likely be some upregulation of the enzyme responsible for breaking down SLU-PP-332 over time.
There’s also the fact that when you take anything making your mitochondria more efficient, there is the potential for free radical and reactive oxygen species (ROS) formation.
So you’ll want your antioxidant agents and ROS scavenger agents at hand, especially during your “off” cycle.
I’m talking about things like Carbon 60, pomegranate extract, Urolithin A, Vitamin C, and other mitochondrial support supplements.
Monitor Your Body
Get comprehensive bloodwork before and after your SLOOP protocol.
I’ve been doing this for over three decades and I STILL get comprehensive labs every 12 weeks without exception.
Pay attention to liver enzymes, lipid panels, fasting glucose, and insulin levels.
The preclinical data shows favorable changes across the board, and that’s been consistent with what I AM seeing in real-world use, but individual responses always vary.
Potential Side Effects to Be Aware Of
Based on both the research and real-world community experience, here’s what you should realistically expect.
Hot flashes and increased sweating, especially during and after training, are the most commonly reported effects.
This effects are merely the compound increasing your thermogenesis, and it’s actually a GOOD sign that it’s working.
Increased sweating can be significant, particularly during exercise.
Some users report noticeably bigger and more defined fast-twitch muscles, better pumps, and much greater energy during cardio alongside the fat loss taking place.
No serious adverse events have been reported in either the published research or within our biohacker community.
Dosing: What We’ve Learned
In my original article about SLU-PP-332, I recommended a daily dose of 500mcg split into two even doses.
It turns out myself and several biohackers were MASSIVELY underdosing this compound.
When you read the papers from Cyrielle Billon, the lead researcher behind SLU-PP-332, the mice studies used 50 mg/kg twice daily, which is 100 mg/kg total in a mouse.
After applying proper allometric scaling, the updated protocol calls for significantly higher doses than what early adopters were using.
BioLongevity Labs’ ShredMAX at 100mg per capsule reflects this updated understanding.
No need to take it with a fat-soluble meal for better absorption… just get your dose in and move on with your day.
Stacking SLU-PP-332 for Maximum Results
SLOOP stacks incredibly well with other fat loss agents.
Monica and I added SLU-PP-332 on top of Retatrutide when preparing for a photoshoot, and it resulted in the easiest and most successful cut of my life.
SLU-PP-332 adds additional nutrition partitioning and increased thermogenesis to give you what I call “Retatrutide on steroids.”
For those using peptides for weight loss, SLU-PP-332 pairs well with GLP-1 receptor agonists, Tesamorelin, and metabolic peptides like MOTS-C.
I’ve also written about stacking it with thermogenic compounds for biohackers pursuing aggressive body recomposition goals.
The Bottom Line on SLU-PP-332 Side Effects
The safety profile of SLU-PP-332,l based on all available preclinical and real-world evidence, leaves no cause for concern.
No liver toxicity, no kidney damage, no cardiac issues, and no severe adverse events in mouse studies.
Hot flashes, increased sweating, and enhanced thermogenesis are observed in human use… signs the compound is doing exactly what it’s designed to do.
The good news about SLU-PP-332 is you don’t have to wait for another 5-10 years until clinical trials are done and the FDA grants it the stamp of approval worshipped by the sick-care medical system.
You can get your hands on it now through BioLongevity Labs.
As with everything I recommend: Cycle intelligently, support your mitochondria, monitor your bloodwork, and approach it as a tool within a comprehensive optimization strategy that includes proper nutrition, training, and hormonal optimization.
Don’t let clickbait scare you away from what may be the single greatest fat loss compound ever created.
Isn’t It Time You Became Fully Optimized To Live Longer And Stronger?
Join my #1 online membership group, Fully Optimized Health to receive guidance from me and an elite group of more than 700 male and female biohackers (who all started out just like you)
And don’t forget to check out our other premium educational content dedicated to helping you fully optimize your health:
Quantum Peptides – the A-to-Z system for anyone (newbies & pros alike) desiring to master peptide use for the first time and forever.
Quantum Testosterone – the A-to-Z system for Men & Women to learn to optimize their hormones for explosive energy, lean muscle, and timeless vitality.
The Ultimate GLP-1 Video Masterclass – how to PROPERLY utilize the world’s most powerful weight loss drugs for enhanced fat loss and overall longevity.
The Modern Woman’s Peptide Course – a must-have resource for any woman seeking to become more feminine, sexier, leaner, and healthier through the use of peptides.
Life Enhanced – Unlock the secrets to TOTAL Mind-Body-Spirit Optimization as Hunter Williams and I teach you how to live at the tip of the spear.
30 Days 2 Shredz – Reprogram Your Mind and Body for Maximum Fat Loss in Minimum Time with our Optimized Fasting Protocol
Monica Campbell’s 3 Day PMF Video Training Program – Ignite unbreakable strength, sculpt lean muscle, and conquer workouts fearlessly with my wife Monica’s 3 Day Video training course.
Positive Muscle Failure Video Training Program – Learn how to lift weights correctly for maximum muscle in minimum time while building the physique of your dreams.
See you on the inside!
