[DISCLAIMER: The information given in this article is for educational and informational purposes only. The author and publisher are not responsible for any adverse effects or consequences of using the suggestions or products discussed in this article. Individual results may vary.]
Last week, I covered the Ventfort peptide bioregulator and how it was essential for blood flow in the human body.
But as bioregulator expert Phil Micans and bioregulator pioneer Dr. Vladmir Khavinson have said before, Ventfort was one of the 3 ESSENTIAL bioregulators to use.
The second one is known as Pinealon, and it too happens to treat multiple disease states while playing nice with other bioregulators and traditional peptides.
It may not act on every single organ system in the body, but it does act on just one tiny tissue that affects multiple biological systems.
This in turn will greatly determine what you think and how you feel every day, so pay close attention!
I’m going to do a deep dive on Pinealon and show you why it should be added to your collection of peptide bioregulators ASAP!
If you’re not familiar with Bioregulators, get ready to be blown away, as they are the older, but new secret weapon to age reversal.
TL;DR – Benefits of Pinealon
Pinealon is a brain-targeting peptide bioregulator that helps optimize your pineal gland function.
Research shows it can:
- Support better sleep and faster jet lag recovery
- Improve memory and mental sharpness
- Aid healthy brain aging
- Enhance physical performance
- Help regulate natural melatonin production
You’ll typically see initial benefits within 2-3 weeks, with full effects developing over 3 months of consistent use.
Before diving into Pinealon or any other peptides, you must know that most people waste hundreds (sometimes thousands) of dollars on peptides because they don’t understand the basics of proper usage.
Want to avoid these costly mistakes?
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What Is Pinealon?
Pinealon is a synthetic peptide bioregulator consisting of only 3 amino acids: Glutamine (Glu, E), Asparagine (Asp, D), and Arginine (Arg, R).
(Source)
Thus, if you still remember my first article on peptide bioregulators, this puts Pinealon in the class of Cytogens.
Every bioregulator is specific to the tissue/organ it targets, and in the case of Pinealon it goes directly after the brain.
Thanks to its ability to cross the blood-brain barrier, Pinealon can help normalize select cognitive functions.
Some of the reported uses, which bioregulator expert Phil Micans informed me of and will be discussed later, include:
- Improvement of physical strength
- Treatment of brain injuries and disorders
- Regulation of sleep cycles
- Neuroprotection against aging-related problems
- Maintenance of memory
Pinealon vs. Endoluten: What’s The Difference?
According to the official IAS website, Endoluten is “a complex of low-molecular peptides with molecular weight up to 5000 Da, isolated from glandulapinealis (epiphysis/ pineal) of young animals – calves aged up to 12 months.… manufactured in the form of tablets or capsules with a content of active substances of 10 mg”
This makes it a Cytomax, a separate class of peptide bioregulator.
However, Pinealon is NOT the synthetic version of Endoluten in the way that Vesugen is the synthetic version of Ventfort… Pinealon itself is a Cytogen isolated from Cortexin.
Don’t forget about the crucial differences between Cytogens (synthetically derived) and Cytomaxes (naturally derived):
- The typical dose of a Cytomax is 10 mg of active substance per capsule, while the typical dose for a Cytogen is 100-125 mcg per capsule
- Cytomaxes contain a group of peptide molecules, while Cytogens contain a single peptide molecule
- Cytomaxes work for longer but don’t work as fast, while Cytogens don’t work for too long but work much faster (hence you treat a medical condition with one round of a Cytogen and then continuously follow up with 10-day treatment rounds of Cytomaxes every 3 months or as needed)
To make the distinction between a Cytoimax and Cytogen when making your purchase, remember the inactive excipients will be the same (microcrystalline cellulose, lactose, etc.)
For instance, the active substance in Pinealon is “Peptide complex AC-5” whereas the active substance in Endoluten is “Peptide complex A-8”.
Look for this difference and there won’t be any confusion.
(In fact, for any peptide bioregulator, “AC” is for synthetic bioregulators and “A” is for natural bioregulators)
How Does Pinealon Work?
While there are many potential mechanisms of action for Pinealon, there are two that stand out to me the most.
One possible mechanism involves the lowering of caspase-3 activity in the brain:
“We studied the effects of the tripeptide pinealon (Lys-Glu-Arg) on behavior and caspase-3 activity in the brain of 21-day-old rats that were subjected to prenatal hypoxia (i.e. low levels of blood oxygen).
We found that administration of pinealon to females during the entire course of pregnancy increased the survival of newborn rat rats that were subjected to prenatal hypoxia.
In these rats, at the age of 21 days the activity of caspase-3 in brain structures was significantly lower as compared to rats that were not treated with pinealon during the pregnancy period.”
This in turn allows for the prevention of unnecessary neuronal cell death), which more evidence shows is bad news for cognitive health:
“…in adults, hypoxic-ischemic neurodegeneration with apoptosis prevalence is related to the activation of the complete caspase cascade, whereas in newborns, caspase-3 is mainly activated. This is related to the ontogenic specificity in the regulation of apoptosis in brain regions.
In particular, the activity of caspase-3 is high in the fetal brain. Moreover, changes in caspase activity during hypoxia/ischemia are now considered not only from the point of neurodegeneration but also as an index of plasticity processes”
A second useful mechanism involves increasing the formation of a hormone called irisin.
This is done by modulating the expression of the gene that encodes for irisin: FNDC5 (fibronectin type III domain containing 5), which has a total of 6 potential binding sites for Pinealon.
Get ready to hear the role irisin plays in your body:
“This hormone regulates thermogenesis, as it promotes “browning” of white adipose tissue and its degradation providing increased energy expenditure during exercise.
Another team of scientists from Astan University (UK) headed by Prof. J. E. Brown showed that irisin treatment led to elongation of telomeres, structural elements of chromosomes determining the life span.
Telomere shortening is a genetic marker of aging. Irisin content positively correlates with telomere size and negatively with human age“
If your first response to “elongation of telomeres” was the peptide Epitalon, you’re thinking the right way.
But before we get into the benefits and discuss how these mechanisms apply to the real world, let’s do a rough overview of how the pineal gland is directly connected to a fully functioning brain and body.
Why is the Pineal Gland Important For Human Health?
Rather than bog you down with a super-technical explanation, I’ll share what Phil Micans told me:
The pineal gland is the size of a pea and sites directly in the center of the brain.
One of its primary jobs is to produce melatonin in response to darkness, which in turn controls your circadian rhythms and informs your body when it is daytime and nighttime.
It’s why when you are in the cinema at 2pm in the afternoon and the lights go out, you start to feel drowsy 30 minutes into the movie.
But you have to think of the pineal gland as the “conductor” of the endocrine system: Without a conductor, an orchestra will only produce noise instead of music.
We know that hormones such as growth hormone and cortisol release first thing in the morning as your impetus to get up and start the day.
Hence the importance of the pineal gland as a controlling gland over the other endocrine glands… since the other glands help or hinder hormone secretion depending on the time of the day, you want your pineal gland finely tuned.
However, this transitions into the importance of melatonin and why Pinealon is a must-have bioregulator:
Most people are unaware of two things about melatonin:
(1) Contrary to popular opinion, the release of melatonin doesn’t make you fall asleep. Rather, it makes you drowsy, but that alone gives you deeper sleep by putting your body in a state of restorative REM sleep.
(2) Melatonin is the most powerful antioxidant your body endogenously produces, and some studies suggest extremely high doses of melatonin could inhibit tumor growth (remember when Doris Loh recommended melatonin during the pandemic?)
<NOTE> In my recent private Webinar with Doris Loh, she made recommendations of up to 2-3 grams of high dose melatonin (HDM) to ward off COVID and various viral pathogens. Rumor has it, using Pinealon in combination with high dose Melatonin provides an ‘out of body’ astral travel experience in ‘some users’.
Therefore, by taking Pinealon, we allow the pineal gland to endogenously produce more melatonin and bring forth all of the downstream health effects.
Which sounds awfully similar to the Melanotan 1 peptide I frequently use to enhance consciousness via pineal gland stimulation.
There are NO COINCIDENCES in the Golden Age of fully optimized health!
Who Benefits the Most from Pinealon
If you’re interested in cognitive enhancement and brain health, Pinealon could be a game-changer.
First, let’s understand something crucial: Pinealon is special because it can cross the blood-brain barrier – essentially the brain’s security system that keeps most substances out.
This means it can directly access and influence brain tissue, making it particularly valuable for several groups:
- Aging Adults Concerned About Cognitive Decline: Your brain naturally experiences some wear and tear as you age (not just figuratively!). A 90-year-old brain weighs at least 100 grams less than an average 40-year-old brain! If you notice minor memory lapses or want to stay mentally sharp, Pinealon may help maintain cognitive function. It works at the genetic level, helping your brain cells operate more efficiently.
- High-Performance Professionals: If your work demands peak mental performance – whether you’re an executive, entrepreneur, or knowledge worker – Pinealon might give you that extra edge. You can enjoy improved focus and mental clarity, which can translate to better decision-making and productivity.
- People with Sleep Disruption: Having trouble with your sleep-wake cycle? Pinealon targets the pineal gland, which regulates your circadian rhythm. This makes it particularly beneficial if you’re dealing with jet lag, shift work, or general sleep disturbances.
- Athletes and Physical Performers: Surprisingly, Pinealon isn’t just about mental performance. The brain-body connection means improved neural function can also improve physical performance.
- Recovery Seekers: If you’re recovering from brain trauma or dealing with post-concussion symptoms, Pinealon’s neuroprotective properties might be especially valuable. It helps support the brain’s natural healing processes.
Unlike many pharmaceutical interventions, Pinealon works with your body’s natural systems.
It does not force changes but rather helps your brain optimize its own function. This makes it particularly attractive if you’re interested in longevity and preventative health approaches.
Pinealon Peptide Bioregulator Benefits
If you try to look up “Pinealon” on PubMed, you’ll get a disappointing total of 20 results… and there are only a few more papers you can find if you get smart with your search queries.
Fear not, as there is enough data to show us how the Pinealon benefits to your health extend far beyond mere party tricks.
Reduced Jet Lag
This one doesn’t have any clinical evidence supporting it (yet), but Phil Micans was eager to present this to me without hesitation.
Given the literature’s support for melatonin use in treating jet lag if timed correctly and dosed appropriately, and what we’ve just learned about endogenous melatonin production, why not just use Pinealon?
Not so fast!
Bioregulators don’t work as rapidly as a standalone melatonin supplement would, so you have to be a bit smarter.
The typical protocol for fixing sleep is to take normal melatonin – NOT extended release or sublingual – between 9 and 11pm, that way you release melatonin at its natural night peak between 1 and 3am.
Now let’s apply it to an example.
Let’s say we’re traveling from the east coast of the United States to Germany, a roughly 8-hour time difference.
What you want to do for the 3 days leading up to your flight is take Pinealon daily between 9-11pm of the DESTINATION’S TIME ZONE.
This will help you take only 1-3 days to get fully adjusted to the new time zone when you arrive, versus 7+ days of feeling chronically tired and unable to get through the day.
Pinealon for Sleep
Quality slumber is a must for cognitive sharpness and emotional well-being.
Unfortunately, about 33% of adults struggle with debilitating insomnia and sleep dysfunction.
What’s particularly concerning is that 27% of those suffering from insomnia didn’t even realize they had the condition.
One Reddit user reported positive results using Pinealon at a 1mg injectable dose per day (though they noted that the 500mcg-1mg range worked fine).
Additionally, when they combined Pinealon with the herb Ho-she-wou, they experienced better sleep quality and increased dream activity, especially vivid lucid dreams.
According to research published in Molecules (2020), Pinealon has some interesting effects on your brain’s sleep-wake cycle.
Your pineal gland (that tiny control center for sleep in your brain) naturally produces melatonin when it gets dark (not necessarily only at night).
When you’re sitting in a dark movie theater at 2 PM and start feeling drowsy after 30 minutes, that’s your pineal gland at work.
Pinealon helps support this natural rhythm through the following:
- Serotonin Regulation: Pinealon stimulates serotonin synthesis in cerebral cortex cells. This is important because serotonin is a precursor to your body’s natural sleep hormone, melatonin.
- Calmodulin Interaction: The peptide interacts with calmodulin (CALM), a crucial protein that helps regulate neurotransmitter release in synapses. This process is fundamental for both sleep regulation and memory formation.
- ERK1/2 Pathway: In neurons, Pinealon increases the activation of ERK1/2 kinase signaling, which is essential for:
- Neuronal survival
- Synaptic plasticity
- Sleep-wake cycle regulation
In a clinical trial, 72 patients aged 30-74 received oral 0.2 mg of Pinealon twice daily for 20-30 days.
The results:
- Improved emotional stability
- Better memory function
- Reduced headache duration and intensity
- Enhanced information processing
Pinealon works differently than regular melatonin supplements, though.
Bioregulators like Pinealon don’t act as quickly as standalone melatonin powders but may offer more sustainable benefits.
They help regulate circadian genes and melatonin synthesis, potentially offering a more comprehensive approach to sleep regulation.
Here’s the best part—unlike many sleep medications, Pinealon appears to work with your body’s natural processes rather than forcing sleep.
It’s like teaching your body to fish instead of giving it fish.
Memory Improvement
In Chapter 5 of the book Peptides in the Epigenetic Control of Ageing, Khavinson and his colleagues talk about three clinical trials done on humans using Pinealon to correct brain damage, whether through external trauma or internal dysfunction.
I couldn’t find the PubMed references for these, so I’ll just paste them verbatim.
Clinical Trial #1:
“In a clinical trial involving 72 patients with cerebral asthenia after cranial trauma (ages 30-74 years), peroral Pinealon (EDR) at the dosage of 0.2 mg twice daily for 20-30 days was added to conventional therapy.
The control group was comprised of 37 patients suffering from similar disorders and treated in the conventional way.
The patients who received Pinealon reported improvements in their memory and emotional stability and decreases in the duration and intensity of headaches.
Regressed focal symptoms and an improvement in speech were observed in those of the patients who had motor or sensory aphasia.
In Pinealon-treated patients tested for the rate of information processing (proof-correction test), the number of errors decreased and the integral workability index increased.”
Clinical Trial #2:
“Pinealon in capsules (one capsule twice daily for two weeks) was given to 75 elderly human subjects to correct the psycho-emotional and functional conditions of the central nervous system.
Improvements of the short-term and long-term memory and decreases in the index of severity of pathological conditions were observed in patients.”
Clinical Trial #3:
“The combined peroral administration of Pinealon and Vesugen (KED) (One capsule twice daily for 30 days) to subjects aged 20 to 75 years who have been being influenced by adverse occupational conditions (150 street vehicle drivers) helped to improve their memory, attention, cognition, perception and motor responses and to decrease the symptoms of aging of the central nervous system.”
Anti-Aging Effects
Russian scientists discovered that Pinealon is a powerful neuroprotective compound that fights cellular aging in your brain.
When combined with another peptide called Vesugen, it shows impressive anabolic effects in neural tissue, potentially slowing down the biological aging markers in your brain.
A study in Advances in Gerontology tested this on 32 people (18 men, 12 women) between 41-83 years old. The results showed:
- Significant anabolic effects
- Improved central nervous system activity
- Slowed aging based on biological markers
- Complete safety at the nuclear genetic level
Pinealon influences something called Irisin, a peptide that’s crucial for cellular resilience.
When your cells are under stress from physical exertion, Irisin helps protect them. It also helps burn fat and—this is the big one—maintains your telomeres.
Telomeres are protective caps on DNA that get shorter as you age. Pinealon helps keep these telomeres intact by supporting Irisin stability.
These anti-aging effects are impressive, but they’re not quite as dramatic as what we see with Epitalon.
Epitalon remains the gold standard for peptide-based lifespan extension. Pinealon is more of a neuroprotective specialist rather than the all-round peptides for anti-aging.
Helps with Depression
Pinealon can boost something called 5-tryptophan hydroxylase.
It is your brain’s natural serotonin factory. Serotonin? That’s your “feel-good” chemical that keeps your mood balanced and your brain protected as you age.
Now, if you’ve ever dealt with depression or know someone who has, you’ve probably heard of SSRIs (Selective Serotonin Reuptake Inhibitors).
These are the most common antidepressant medications doctors prescribe. But the problem is they often come with many unwanted side effects that can make you feel… well, not quite yourself.
On the other hand, Pinealon does not force your brain to recycle existing serotonin (which is what SSRIs do) but helps your brain produce more serotonin naturally.
Much like another powerful peptide, MIF-1, which is revolutionizing treatment-resistant depression, Pinealon works with your body’s natural processes.
It is more physiologic and thus reduces side effects.
Improving Physical Strength
In Chapter 3 of the book The Peptide Bioregulator Revolution, I found an interesting study involving the use of Pinealon in combination with another peptide bioregulator for the immune system.
Sadly there isn’t any hard data available on this study, but if confirmed, it would be a good example of how Pinealon’s use wouldn’t be limited to just older individuals with some kind of clear medical problem:
“Pinealon, together with Crystagen, were given to athletes at a dose of 0.1 mg twice a day for two weeks.
Their performance improved, with better adaptation to exercise, better immunity and a reduced incidence of respiratory disease, increased antioxidant protection, and improved metabolism parameters.
There was a direct relationship with genes which improve metabolism in exercising muscles (such as the PPARA and PPARG genes) as well as improvement in immune activation markers such as CD71, CD25, HLA-DR and the levels of M, G, and E immunoglobulins.”
Pinealon Dosage
The Pinealon dose you should be taking regardless of your medical condition is the following:
1-2 capsules taken once or twice daily (30 minutes before meals) for a month, repeating the cycle every 4-6 months as needed.
If you’re going with Endoluten, the recommendations are slightly different:
- For normal use, 2 capsules a day for a month
- For treating stress and general debility, 1 capsule two to three times a day
- Cycle every 3-6 months depending on recovery
Phil Micans informed me that highly aware and sensitive people may see changes within the first 2-3 weeks, noticing better sleep (not necessarily more sleep).
However, and even with taking into account we are all N-of-1, the big changes you’ll experience with Pinealon need at least 3 months to take effect.
The general recommendations for Pinealon are the same as for Ventfort:
- Avoid use if pregnant or breastfeeding
- Store Pinealon in a cool, dark, dry place at room temperature away from direct sunlight
- Double-check the ingredients to see if you are allergic to anything
- Follow the dosing recommendations exactly.. LESS is MORE
What About Pinealon Injections?
If you browse the Internet for just a few seconds, you’ll see the majority of peptide vendors offering Pinealon in the form of a lyophilized peptide you have to reconstitute for subcutaneous injections.
So what should you take – the oral capsules or the injections?
Based on what we KNOW about peptide bioregulators’ amazing ability to work orally as they are tissue specific and Phil Micans’ first-hand experience, I would stick with the capsules.
Even though the injections would have greater bioavailability, the bioregulators are so small to the point where they will pass through the stomach wall and not be destroyed to any great degree.
There’s also a few problems with the injections at face value:
- Most people are needle phobic, and simply don’t want to have needles stuck in them
- Due to the route of administration, injections become a prescribed and ‘medically restricted’ medical treatment (versus the bioregulators’ status as food supplements)
- You don’t have to take the oral peptides every day
In the case of injectable bioregulators, you’ll only see them in limited cases with people who have real medical needs.
Something like an eye disorder would be treated with a daily injection in the orbital fat for 10 days straight, done every 6-12 months.
In the time periods between injections, the patient would be using the oral peptide bioregulators.
Long story short… you’ll be just fine with Pinealon in its original oral form!
How to Take Pinealon for Maximum Benefit
Your body’s response to Pinealon largely depends on your genetics and neurochemistry.
The compound regulates specific gene expression pathways involved in sleep-wake cycles and the brain’s cellular repair mechanisms.
But here’s the thing about working with your genes – it’s not an overnight fix. It’s like teaching your body a new language. Your cells need time to learn and adapt.
Here’s what you MUST know:
- Pair it with some healthy fats. Your body needs these to properly absorb and transport the compound where it needs to go.
- AVOID taking it with acidic foods or drinks – they’ll wreck Pinealon’s structure.
- Stay away from caffeine within 6 hours of taking Pinealon—it interferes with its ability to optimize brain function.
- Storage matters more than you think! Keep it cool and dry, away from light, or you might as well be throwing your money away.
One thing you should also know about Pinealon is that it cranks up your IGF-1 levels.
Why should you care? Because higher IGF-1 equals better sleep quality.
To capitalize on this, keep your protein intake solid and stay hydrated. Your body will thank you for it.
Here is some general advice every good cognitive enhancement guru will give that may enhance Pinealon’s effectiveness:
- Get morning sunlight exposure (15-30 minutes)
- Reduce blue light exposure 2-3 hours before bedtime
- Exercise preferably in the morning or early afternoon
- Avoid intense exercise 3-4 hours before bedtime
Movement helps regulate neurotransmitters that Pinealon interacts with.
Where To Buy Pinealon
When it comes to legitimate peptide bioregulators sourced and synthesized properly, Profound Health (a subset of International Antiaging Systems) is the only place you need to know about.
They have Pinealon, Endoluten, and several other bioregulators I plan to write about in the very near future.
Use code JAY15 to get 15% off your order!
International shipping, +1000 articles on bioregulators, free magazine issues, a +30 year history… you’ll be hard-pressed to find any company with that kind of reputation and longevity in a world where peptides are being suppressed.
Frequently Asked Questions (FAQs)
Let’s address some common questions about Pinealon’s benefits and usage:
How Quickly Can Pinealon Benefits Be Felt?
You may see initial effects within 2-3 weeks, though timing varies by individual:
- Sleep improvements: 1-2 weeks
- Cognitive benefits: 2-4 weeks
- Full effects: 3 months
What Are the Common Pinealon Side Effects?
Pinealon is generally well-tolerated like any other peptide bioregulators, but some users may experience:
- Mild headaches (usually temporary)
- Slight dizziness (due to longer sleep)
- Initial sleep pattern disturbances
Can Pinealon Be Combined with Other Supplements for Enhanced Benefits?
So far, no negative interactions between Pinealon and other common supplements have been identified.
However, little data exists on Pinealon’s safety with complex multi-ingredient formulas.
Taking magnesium supplements for improved sleep quality or B-complex vitamins for better energy metabolism should be safe.
You might avoid uncertain combinations until more research comes out or consult your physician first.
Is Pinealon Safe for Long-Term Use?
Current data suggests Pinealon is well-tolerated, but insufficient evidence exists to confirm its long-term safety just yet.
Most human trials have only evaluated effects over several weeks or months.
Assess your risks and benefits when considering ongoing Pinealon peptide supplementation.
Conclusion: Control The Brain, Control Your Life
The Pinealon peptide bioregulator is a fascinating compound because of how it controls a tiny little gland that greatly influences many other systems in your body.
It’s interesting to see science finally catch up to what many of the ancient civilizations knew thousands of years ago, but now we have the tools to activate the brain and access higher levels of consciousness.
And if you KNOW me by now, what is more important than helping humanity reach a higher state of consciousness at the current moment?
At the very least, we can repair some forms of cognitive dysfunction and reach a point where we are no longer inhibited by low-vibration thinking and emotional drainages.
As always…
Raise Your Vibration To Optimize Your Love Creation!
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