Are you struggling to shed those stubborn pounds and inches despite using various diets, exercise routines, and other fast weight-loss strategies?
Fortunately, there’s a peptide naturally produced in your body that helps regulate blood sugar levels and can also help you lose body fat.
This peptide is called glucagon-like peptide 1 (GLP-1).
But as a Jay Campbell reader you already knew that.
And you already KNOW about the many studies backing up its vital role in weight loss… for example, one paper published in JAMA Network found that individuals who took GLP-1 agonist Semaglutide lost an average of 15.8% body weight after using it for 68 weeks.
But that’s not all… pairing GLP-1 elevating compounds with a healthy lifestyle and eating an insulin-controlled diet can further accelerate how fast you lose fat and how much of it you lose.
If you’re new to my ecosystem and are curious about how GLP-1 can help you reach your fat loss goals, you’ve come to the right place.
If you’re a veteran reader, consider this a refresher on the ABCs.
What is GLP-1?
GLP-1, a peptide hormone naturally produced in the L-cells of the ileum and colon, is released into your gut every time you eat.
This hormone plays a crucial role in regulating blood glucose levels, which explains why it initially had its quiet start as a valuable treatment for type 2 diabetes mellitus.
While it doesn’t directly promote fat loss through mechanisms such as elevated basal metabolic rate or increased lipolysis, it is nevertheless beneficial for people aiming to lose excess weight.
GLP-1 has earned its reputation as a weight loss target because it’s also involved in managing insulin secretion, controlling hunger, and delaying gastric emptying of the stomach.
Literally, you lose the desire to eat in general and even attempting to force-feed yourself after using a GLP-1 agonist will make you feel uneasy.
In short… it’s the unrivaled appetite suppression that FINALLY gives people the mental control they’ve always desired over their bad dietary habits around consuming excess calories (and the “bad” calories especially).
How Do GLP-1 Agonists Work?
If you’ve been researching ways to lose body fat, you may have stumbled across the wonderful world of biohacking for weight loss.
One proven yet still promising avenue in this field is the use of GLP-1 agonists.
GLP-1 agonists work by mimicking the effects of GLP-1, a peptide hormone released from the small intestine after eating.
As I just mentioned, this peptide hormone helps regulate blood sugar levels by stimulating the pancreas to release insulin.
Insulin then helps manage blood sugar by promoting the uptake of glucose by cells and inhibiting the liver from releasing excess sugar into the bloodstream.
Additionally, GLP-1 agonists help control glucagon secretion, further aiding in regulating blood sugar levels.
Thirdly and finally, by activating receptors in the brain that control hunger, GLP-1 agonists can help you feel full and satisfied with smaller portions, leading to a smaller appetite and consequently a reduced calorie intake.
This is achieved by delaying the emptying of the stomach, which promotes the gradual absorption of nutrients and further stabilizes blood sugar levels.
This can be particularly beneficial for individuals looking to manage their weight or improve their overall health (usually both for the dumpster fires!).
Who Should Use GLP-1 Agonist Supplements?
However, it should be emphasized that GLP-1 agonists aren’t a one-size-fits-all solution… nor are they “officially” recommended for people who are just trying to shed a few pounds.
To qualify for an insurance covered prescription of agents like Semaglutide and its successor Tirzepatide, you need to meet specific FDA guidelines.
This includes having a body mass index (BMI) of at least 30 or a BMI of at least 27 with at least one weight-related condition (ex. high cholesterol, type 2 diabetes, or high blood pressure).
There are also certain groups for whom GLP-1 agonists are not recommended.
- Pregnant women
- Patients with digestive conditions like inflammatory bowel disease (IBD) or gastroparesis
- People with a family or personal history of pancreatitis or thyroid issues (i.e. multiple endocrine neoplasia or medullary thyroid cancer)
Before you use any GLP-1 agonists, always consult a doctor to determine if they are right for you based on your medical history and weight loss goals.
The Best Evidence-Based GLP-1 Supplements
A fully optimized lifestyle remains the most effective and cost-efficient method to naturally boost GLP-1 levels.
But if you want to take things one step further and specifically target your body’s GLP-1 production, you might want to check out the following options.
Berberine
Berberine is an alkaloid that is found in the roots, bark, leaves, and stems of certain plants like goldenseal, barberry, tree turmeric, and Oregon grape.
Apart from its antimicrobial and antidiarrheal properties, which help with infections and gastrointestinal disorders, berberine also induces GLP-1 secretion in the intestine to manage blood sugar and reduce hyperglycemia.
In one study with rats, those given Berberine had boosted GLP-1 secretion and maintained healthy blood sugar levels.
“In vivo, a 5-week treatment of berberine enhanced GLP-1 secretion induced by glucose load and promoted proglucagon mRNA expression as well as L cell proliferation in the intestine.
In vitro, berberine concentration-dependently stimulated GLP-1 release in NCI-H716 cells. Berberine also promoted both prohormone convertase 3 and proglucagon mRNA expression. Chelerythrine (inhibitor of PKC) concentration-dependently suppressed berberine-mediated GLP-1 secretion.
Compound C (inhibitor of AMPK) also inhibited berberine-mediated GLP-1 secretion. But only low concentrations of H89 (inhibitor of PKA) showed inhibitory effects on berberine-mediated GLP-1 release.
The present results demonstrated that berberine showed its modulation on GLP-1 via promoting GLP-1 secretion and GLP-1 biosynthesis.
Some signal pathways including PKC-dependent pathway were involved in this process. Elucidation of mechanisms controlling berberine-mediated GLP-1 secretion may facilitate the understanding of berberine’s antidiabetic effects.”
Moreover, as it’s considered to be “nature’s Ozempic” by the media, Berberine may possibly help you lose stubborn fat.
A review of 12 studies showed that people given 500 mg daily of Berberine lost an average of 4 pounds.
“Berberine treatment moderately but significantly decreased body weight (WMD = −2.07 kg, 95% CI -3.09, −1.05, P < 0.001), body mass index (BMI) (WMD = −0.47 kg/m2, 95% CI -0.70, −0.23, P < 0.001), waist circumference (WC) (WMD = −1.08 cm, 95% CI -1.97, −0.19, P = 0.018) and C-reactive protein (CRP) concentrations (WMD = −0.42 mg/L, 95% CI -0.82, −0.03, P = 0.034).
However, berberine intake did not affect liver enzymes, including alanine aminotransferase (ALT) (WMD = −1.66 I/U, 95% CI -3.98, 0.65, P = 0.160) and aspartate aminotransferase (AST) (WMD = −0.87 I/U, 95% CI -2.56, 0.82, P = 0.311).”
Calocurb
Calocurb is a natural GLP-1 activating supplement designed to help you manage compulsive overeating, uncontrollable cravings, ravenous hunger, and habitual snacking between meals.
(Read my deep-dive article here for a FULL write-up about this game-changing agent)
Manufactured in the USA, Calocurb uses 100% all-natural plant-based ingredients.
Without diving deeper into its rich 13-year history, Calocurb originated from a $25 million government grant to the New Zealand Institute for Plant and Food Research.
After rigorous screening of nearly 1,000 herbal compounds, Calocurb was developed to stimulate the release of satiety hormones that reduce acute hunger.
The key ingredient, Amarasate, triggers the release of three hormones in the gastrointestinal tract (CCK, GLP-1, PPY) that synergistically signal the brain to lower the appetite and delay gastric emptying (hence the prolonged feeling of fullness many users report back).
This effect lasts up to four hours, and Amarasate is mostly metabolized in the large colon within 24 hours, ensuring no negative effects on the kidneys.
The supplement’s high concentration of alpha acids (bitter compounds) has been shown in research to help lower calorie intake.
In a study in The American Journal of Clinical Nutrition, men given Calocurb one hour before a meal ate 18% fewer calories compared to the placebo group:
“Nineteen healthy-weight men completed a randomized 3-treatment, double-blind, crossover study with a 1-week washout between treatments.
Treatments comprised either a placebo or 500 mg of hop extract administered in delayed-release capsules (duodenal) at 11:00 h or quick-release capsules (gastric) at 11:30 h.
Ad libitum EI was recorded at the lunch (12:00 h) and afternoon snack (14:00 h), with blood samples taken and subjective ratings of appetite, gastrointestinal (GI) discomfort, vitality, meal palatability, and mood assessed throughout the day.
Total ad libitum EI was reduced following both the gastric (4473 kJ; 95% CI: 3811, 5134; P = 0.006) and duodenal (4439 kJ; 95% CI: 3777, 5102; P = 0.004) hop treatments compared with the placebo (5383 kJ; 95% CI: 4722, 6045).
Gastric and duodenal treatments stimulated prelunch ghrelin secretion and postprandial cholecystokinin, glucagon-like peptide 1, and peptide YY responses compared with placebo.
In contrast, postprandial insulin, glucose-dependent insulinotropic peptide, and pancreatic polypeptide responses were reduced in gastric and duodenal treatments without affecting glycemia.
In addition, gastric and duodenal treatments produced small but significant increases in subjective measures of GI discomfort (e.g., nausea, bloating, abdominal discomfort) with mild to severe adverse GI symptoms reported in the gastric treatment only.
However, no significant treatment effects were observed for any subjective measures of appetite or meal palatability.”
My wife, Monica, can vouch for these results.
With just two capsules of Calocurb a day, she can now effortlessly fast for 22 hours – a milestone she couldn’t reach before, struggling to go beyond 18 hours.
Therefore, if your goal is to eat less while feeling fuller, Calocurb should be your go-to.
*IMPORTANT* Calocurb works in most people but everyone has a different dosage level to achieve peak appetite suppression.
I use between 3-8 capsules per day to effectively suppress my appetite when doing longer fast intervals like those found in 30 Days 2 Shredz
Semaglutide
Semaglutide is a GLP-1 agonist approved by the U.S. Food and Drug Administration (FDA) under the brand names Rybelsus and Ozempic for managing type 2 diabetes.
It’s also known as Wegovy, a weight loss peptide used by people with obesity and excess weight to help them shed body fat.
At both lower and higher doses, the peptide helps suppress appetite and slows down gastric emptying, thus promoting weight loss.
However, you can achieve the best results when you combine the peptide with a healthy insulin controlled diet and exercise.
(NOTE: Please read Dr. Eberwein’s exhaustive write-up debunking the myths about Semaglutide and educating people on how to maximize the results they get from any GLP-1 agonist)
This has been shown in two studies published in JAMA Network.
In the first study, adults with obesity and excess weight given 2.4 mg semaglutide once weekly had a 10.6% weight loss for up to 48 weeks.
“A total of 902 participants received once-weekly subcutaneous semaglutide during run-in.
After 20 weeks (16 weeks of dose escalation; 4 weeks of maintenance dose), 803 participants (89.0%) who reached the 2.4-mg/wk semaglutide maintenance dose were randomized (2:1) to 48 weeks of continued subcutaneous semaglutide (n = 535) or switched to placebo (n = 268), plus lifestyle intervention in both groups.
Among 803 study participants who completed the 20-week run-in period (with a mean weight loss of 10.6%) and were randomized (mean age, 46 [SD, 12] years; 634 [79%] women; mean body weight, 107.2 kg [SD, 22.7 kg]), 787 participants (98.0%) completed the trial and 741 (92.3%) completed treatment.
With continued semaglutide, mean body weight change from week 20 to week 68 was −7.9% vs +6.9% with the switch to placebo (difference, −14.8 [95% CI, −16.0 to −13.5] percentage points; P < .001).
Waist circumference (−9.7 cm [95% CI, −10.9 to −8.5 cm]), systolic blood pressure (−3.9 mm Hg [95% CI, −5.8 to −2.0 mm Hg]), and SF-36 physical functioning score (2.5 [95% CI, 1.6-3.3]) also improved with continued subcutaneous semaglutide vs placebo (all P < .001).
Gastrointestinal events were reported in 41.9% of participants who continued subcutaneous semaglutide vs 26.1% with placebo; similar proportions discontinued treatment because of adverse events with continued semaglutide (2.4%) and placebo (2.2%).”
In the second study, those given Semaglutide along with intensive behavioral therapy and an initial low-calorie diet showed greater weight loss during 68 weeks of using the GLP-1 agonist:
“Randomized, double-blind, parallel-group, 68-week, phase 3a study (STEP 3) conducted at 41 sites in the US from August 2018 to April 2020 in adults without diabetes (N = 611) and with either overweight (body mass index ≥27) plus at least 1 comorbidity or obesity (body mass index ≥30).
Participants were randomized (2:1) to semaglutide, 2.4 mg (n = 407) or placebo (n = 204), both combined with a low-calorie diet for the first 8 weeks and intensive behavioral therapy (ie, 30 counseling visits) during 68 weeks.
Of 611 randomized participants (495 women [81.0%], mean age 46 years [SD, 13], body weight 105.8 kg [SD, 22.9], and body mass index 38.0 [SD, 6.7]), 567 (92.8%) completed the trial, and 505 (82.7%) were receiving treatment at trial end.
At week 68, the estimated mean body weight change from baseline was –16.0% for semaglutide vs –5.7% for placebo (difference, −10.3 percentage points [95% CI, −12.0 to −8.6]; P < .001).
More participants treated with semaglutide vs placebo lost at least 5% of baseline body weight (86.6% vs 47.6%, respectively; P < .001).
A higher proportion of participants in the semaglutide vs placebo group achieved weight losses of at least 10% or 15% (75.3% vs 27.0% and 55.8% vs 13.2%, respectively; P < .001). Gastrointestinal adverse events were more frequent with semaglutide (82.8%) vs placebo (63.2%). Treatment was discontinued owing to these events in 3.4% of semaglutide participants vs 0% of placebo participants.”
If you’re worried about some of the Semaglutide myths, one being the FEAR of losing muscle mass while losing weight, make sure to read Dr. Eberwein’s write-up I just mentioned a few sentences ago.
As long as you maintain a healthy diet and habits, such as eating a high-protein diet, doing resistance training, taking amino acid supplements, and having an optimized mindset, you can build and preserve lean muscle while losing body fat.
Ginseng
Ginseng has been a go-to in Chinese and alternative medicine for ages, as it is known to boost both physical and emotional well-being while providing a lift in energy levels.
Recent studies suggest it might also boost GLP-1, helping you achieve better blood sugar control, a healthier heart, and lower blood pressure – all especially beneficial for people with type 2 diabetes.
In fact, rats given ginseng compounds for 4 weeks had boosted GLP-1 release, improving their blood sugar and cholesterol levels, as published in the Journal of Endocrinology:
“Panax ginseng is one of the most popular herbal remedies. Ginsenosides, major bioactive constituents in P. ginseng, have shown good antidiabetic action, but the precise mechanism was not fully understood.
Glucagon-like peptide-1 (GLP1) is considered to be an important incretin that can regulate glucose homeostasis in the gastrointestinal tract after meals.
Ginsenoside Rb1 (Rb1), the most abundant constituent in GTS, was selected to further explore the underlying mechanisms in cultured NCI-H716 cells.
Diabetic rats were developed by a combination of high-fat diet and low-dose streptozotocin injection. The diabetic rats orally received GTS (150 or 300 mg/kg) daily for 4 weeks.
It was found that GTS treatment significantly ameliorated hyperglycemia and dyslipidemia, accompanied by a significant increase in glucose-induced GLP1 secretion and upregulation of proglucagon gene expression.
Data from NCI-H716 cells showed that both GTS and Rb1 promoted GLP1 secretion.
It was observed that Rb1 increased the ratio of intracellular ATP to ADP concentration and intracellular Ca2+ concentration. The metabolic inhibitor azide (3 mM), the KATP channel opener diazoxide (340 μM), and the Ca2+ channel blocker nifedipine (20 μM) significantly reversed Rb1-mediated GLP1 secretion.”
And in a review of human studies in the Journal of Molecules, ginseng also helped reduce fasting blood glucose in people with diabetes compared to the control group:
“Shishtar et al. found ginseng significantly reduced fasting blood glucose compared to the control (−0.31 mmol/L [95% CI: −0.59 to −0.03], p = 0.03) based on a meta-analysis of sixteen randomized controlled clinical trials; there was no significant effect on fasting plasma insulin and glycated hemoglobin.
Another meta-analysis included eight trials that suggested ginseng supplementation showed significant differences on fasting glucose (−0.306 mmol/L [95% CI: −0.539 to −0.074], p = 0.01), postprandial insulin (−2.132 mmol/L [95% CI: −3.706 to −0.558], p = 0.008), and HOMA-IR (−0.397 mmol/L [95% CI: −0.679 to −0.115], p = 0.006) compared to the control group; there was no significant difference on postprandial glucose and fasting insulin between ginseng treatment and control groups.”
Resveratrol
Resveratrol is a natural compound found in certain plant foods, including red grapes, berries, and peanuts.
Aside from its antioxidant, anti-inflammatory, and anti-cancer properties, resveratrol can also stimulate the production and release of GLP-1.
Theoretically, by increasing GLP-1 levels, resveratrol may help reduce food intake and promote weight loss.
A PLoS One study discovered that resveratrol can help lower glycemia in rats with type 2 diabetes due to its ability to produce and release glucagon-like peptide 1 (GLP-1).
Again… it slows gastric emptying, stimulates insulin secretion, and suppresses glucagon secretion and energy intake:
“Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear.
We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice.
Administration of RSV for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both Glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1.
This was associated with increased levels of colonic proglucagon mRNA transcripts. RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice.
Conversely, levels of active GLP-1 and control of glycemia were further improved when the Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin was co-administered with RSV.
In addition, RSV treatment modified gut microbiota and decreased the inflammatory status of mice. Our data suggest that RSV exerts its actions in part through modulation of the enteroendocrine axis in vivo.”
Curcumin
Curcumin, the active compound in turmeric responsible for its vibrant yellow hue and powerful anti-inflammatory properties, is gaining attention for its potential health benefits.
Studies suggest that curcumin may help reduce pain and inflammation, making it a potential ally to aid with conditions like arthritis, depression, and inflammatory digestive disorders.
Recent research also indicates that curcumin might have anti-glycemic effects by stimulating GLP-1 production, which could improve glucose control.
In a study published in the Molecular Nutrition & Food Research, curcumin improved blood sugar control in rats by increasing their release of GLP-1 in the body:
“Glucagon-like peptide-1 (GLP-1) is a type of incretin secreted from enteroendocrine L-cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP-1 in enteroendocrine L cell line (GLUTag cells).
However, it is not clear whether its action in vivo directly enhances GLP-1 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin-induced GLP-1 secretion has not been clarified.
Glucose tolerance was significantly improved in rats after pre-administered curcumin (1.5 mg/kg) followed by intraperitoneal glucose injections via the stimulation of GLP-1 secretion and the induction of insulin secretion.
In GLUTag cells, curcumin-induced GLP-1 secretion was associated with G protein-coupled receptor (GPR) 40/120. Furthermore, the glucose-lowering effect induced by curcumin was significantly reduced after the administration of a GPR40/120 antagonist in rats.”
Similarly, in the Journal of Diabetology & Metabolic Syndrome, test subjects given 1,500 mg of curcumin daily resulted in reduced weight and blood sugar in people with type 2 diabetes.
“In this randomized, double-blind, placebo-controlled trial, 53 participants with type 2 diabetes were divided randomly into the experimental and control groups to receive either 1500 mg curcumin or placebo capsule three times in a day for 10 weeks.
Supplementation with curcumin in type 2 diabetes compare to placebo causes a significant changes in mean weight (− 0.64 ± 0.22 vs. 0.19 ± 0.37 p < 0.05), body mass index (BMI) (0.3 ± 0.03 vs. 0.1 ± 0 p < 0.05), waist circumference (WC) (− 1.2 ± 0.4 vs. − 0.43 ± 0.11 p < 0.05) and fasting blood sugar (FBS) (− 7 ± 2 vs. 3 ± 0.2 p < 0.05) but did not show any difference for hemoglobin A1c (HbA1c), insulin, malondialdehyde (MDA), total antioxidant capacity (TAC), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and pancreatic B cell function (HOMA-B) at end of study.”
Whey Protein
Protein is crucial for your body, not just to build strength and recover faster from workouts, but to feel full and satisfied.
Getting enough protein can also help you maintain muscle mass when you’re trying to shed pounds.
Recent studies discovered that daily protein supplements, especially when paired with calcium, might boost the metabolic effects of GLP-1 and potentially aid in weight loss:
“The present study aimed to evaluate the appetite-suppressant effect of an isocaloric drink containing whey proteins or maltodextrins on appetite (satiety/hunger measured by a visual analogue scale or VAS), anorexigenic gastrointestinal peptides (circulating levels of glucagon-like peptide 1 (GLP-1) and peptide tyrosine tyrosine (PYY)) and amino acids (circulating levels of single, total [TAA] and branched-chain amino acids [BCAA]) in a cohort of obese female subjects (n = 8; age: 18.4 ± 3.1 years; body mass index, BMI: 39.2 ± 4.6 kg/m2).
Each drink significantly increased satiety and decreased hunger, the effects being more evident with whey proteins than maltodextrins.
Similarly, circulating levels of GLP-1, PYY and amino acids (TAA, BCAA and alanine, arginine, asparagine, citrulline, glutamine, hydroxyproline, isoleucine, histidine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tyrosine, and valine) were significantly higher with whey proteins than maltodextrins.
In subjects administered whey proteins (but not maltodextrins), isoleucine, leucine, lysine, methionine, phenylalanine, proline, tyrosine, and valine were significantly correlated with hunger (negatively), satiety, and GLP-1 (positively).
Eight specific amino acids (isoleucine, leucine, lysine, methionine, phenylalanine, proline, tyrosine, and valine) were implicated in the appetite-suppressant and GLP-1-stimulating effects of whey proteins, which may be mediated by their binding with nutrient-sensing receptors expressed by L cells within the gastrointestinal wall.
The long-term satiating effect of whey proteins and the effectiveness of supplementation with these amino acids (i.e., as a nutraceutical intervention) administered during body weight reduction programs need to be further investigated.”
GLP-1 Medications vs. Supplements
GLP-1 supplements are marketed as dietary supplements that can boost the production or release of GLP-1.
These supplements often contain fiber, herbs, and probiotics.
On the other hand, GLP-1 drugs are prescription medications used to manage type 2 diabetes mellitus and obesity.
They mimic the action of naturally-occurring GLP-1 and are typically administered via subcutaneous injection once a week (or once a month, although this is extremely rare).
While generally well-tolerated, they may cause mild side effects such as nausea, vomiting, diarrhea, and abdominal pain.
If you’re thinking about trying a GLP-1 supplement or medication, it’s best to consult your doctor first and determine if they are the right choice for your weight loss efforts.
GLP-1 Agonist Safety and Side Effects
As just stated, digestive issues like diarrhea, bloating, constipation, nausea, and vomiting are among the most common side effects of GLP-1 agonists reported.
Other well-known side effects include dizziness, headaches, and fatigue.
To minimize abdominal discomfort, it’s advisable to start with lower doses and gradually taper up.
Despite these “official” side effects, the benefits of using GLP-1 agonists often outweigh the risks associated with them.
Jay’s Closing Thoughts
Don’t bother with compounds like Berberine, Curcumin, Resveratrol and Ginger for increasing GLP-1 production in your body.
They may “show” an effect in published animal and human studies… but I can assure you they are NOTHING compared to Calocurb and the primary GLP-1 agonists Semaglutide and Tirzepatide.
It would be like comparing a toy car to a Ferrari and I mean this in the most literal way.
I AM including them in this article to merely show you just how exhaustively studied the GLP-1 pathway is and a small fraction of the hundreds of avenues explored to target this peptide hormone.
If those natural compounds were even remotely on par with Semaglutide — which is vastly inferior to Tirzepatide and its soon-to-be-successor Retatrutide — companies like Eli Lilly and Novo Nordisk wouldn’t have billion-dollar drugs on the market.
That’s not an exaggeration, either; the GLP-1 agonists are breaking records with each passing day as the fastest-rising AND best-selling drugs in all of pharmaceutical industry history.
(NOTE: For you OG biohackers from the 90s, the exploding popularity of GLP-1 is what would have happened for leptin-targeting drugs if they actually worked once we discovered its role as a master hormone for weight loss that goes above and beyond lowering food intake)
Stick with my two recommendations, educate yourself on the facts and fiction, and you won’t have to worry about constant fear-mongering or hype from sick-care allopathic medicine and mainstream “journalism”.
Key Takeaways for GLP-1 Supplementation
GLP-1 agonists are a helpful tool for managing weight, although it’s crucial to understand that various factors influence obesity.
To effectively help you lose body fat, a comprehensive approach is necessary… dietary changes, exercise plans, and lifestyle habits must be present IN ADDITION to fat loss medications like GLP-1 agonists.
It’s also important to note GLP-1 agonists are not designed for long-term use when used properly.
Research funded by Novo Nordisk suggests on average, people regain two-thirds of their lost weight within a year of stopping Semaglutide.
(Of course, you would know WHY this is misleading if you read Dr. Eberwein’s article I linked to earlier in this article).
Consult with an expert before taking any GLP-1 supplementation, and make sure you only use the safest and most effective GLP-1 agonists on the market.
We highly recommend Limitless Life Nootropics because they are the biohacking industry’s only reliable source for 3rd-party tested research products.
They have some of the best research formulations of fat-loss peptides on the market — Semaglutide, Tirzepatide, and Retatrutide.
Unlike the other peptides, you have to be a card-carrying member of the free-to-join JayC VIP Insider Group if you want to access them.
CLICK HERE to Become a Member
CLICK HERE to Log In & Purchase
(Don’t forget Calocurb as a viable short-term appetite suppressant and a “bridge” to get on or off GLP-1 agonists, which you can get here at 10% off with code JAY10.
Before you ask, I use 2-4 capsules twice per day depending on the level of appetite suppression I AM looking for during long fast windows.)
But before you start injecting these peptides into your body recklessly, make sure you first read the Top 10 Mistakes People Make When Starting Therapeutic Peptides FREE PDF!
Seriously, this short e-book will save you a lot of wasted money and poorly spent time (not to mention preventing you from potential self-inflicted missteps).
And the emails I’ll send you after downloading the book contain an EXCLUSIVE 33% OFF code for my Peptides Demystified Course, so don’t miss out!
Raise Your Vibration To Optimize Your Love Creation!
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